PROMISCUITY

作品数：11被引量：30H指数：3
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相关领域：理学医药卫生更多>>
相关作者：赵伟光更多>>
相关机构：济宁市技师学院更多>>
相关期刊：《Signal Transduction and Targeted Therapy》《Chemical Research in Chinese Universities》《Current Zoology》《Molecular Plant》更多>>
相关基金：国家自然科学基金中国博士后科学基金World Health Organization更多>>
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Molecular characterization and structure basis of a malonyltransferase with both substrate promiscuity and catalytic regiospecificity from Cistanche tubulosa
《Acta Pharmaceutica Sinica B》2024年第5期2333-2348,共16页Xiao Liu Yuyu Liu Xiping Xu Wenqian Huang Yaru Yan Yingxia Wang Weisheng Tian Ting Mo Xiaoxue Cui Jun Li She-Po Shi Pengfei Tu 
This work was financially supported by National Key Research and Development Program Special Project of Synthetic Biology(Grant No.2023YFA0914100/2023YFA0914103);National Natural Science Foundation of China(Grant No.82173922,81402809);Beijing Natural Science Foundation(Grant No.7192112);Fundamental Research Funds for the Central Universities(Grant No.2023-JYB-JBQN-054,China);Young Elite Scientists Sponsorship Program by CAST(Grant No.CACM-2018-QNRC1-02,China);State Key Laboratory of Natural and Biomimetic Drugs Foundation(Grant No.K202119,China).
Enzymatic malonylation of natural glycosides provides a promising alternative method for drug-like malonylated glycosides supply.However,the catalytic potential and structural basis of plant malonyltransferase are far...
关键词：Plant acyltransferase Malonyltransferase Malonylated glycosides Enzymatic catalysis Enzyme promiscuity 
Plant cytochrome P450 plasticity and evolution被引量：13
《Molecular Plant》2021年第8期1244-1265,共22页Cecilie Cetti Hansen David R.Nelson Birger Lindberg Moller Daniele Werck-Reichhart 
supported by a PhD fellowship provided through a Villum Foundation Young Investigator Program fellowship granted to Elizabeth H.J.Neils on(grant number 13167);supported by the VILLUM Center for Plant Plasticity(VKR023054)(B.L.M.);a European Research Council Advanced Grant(ERC-2012-ADG_20120314);the Novo Nordisk Foundation Distinguished Investigator 2019 Grant(NNF 0054563,The Black Holes in the Plant Universe).
The superfamily of cytochrome P450(CYP)enzymes plays key roles in plant evolution and metabolic diversification.This review provides a status on the CYP Iandscape within green algae and land plants.The 11 conserved CY...
关键词：land plants green algae diversificati on PROMISCUITY NEOFUNCTIONALIZATION convergent evolution FUNCTIONALITIES plant metabolism 
Genome Mining and Biosynthesis Study of a Type B Linaridin Reveals a Highly Versatileα-N-Methyltransferase被引量：2
《CCS Chemistry》2021年第3期1049-1057,共9页Fangting Wang Wanqing Wei Junfeng Zhao Tianlu Mo Xin Wang Xuedong Huang Suze Ma Shu Wang Zixin Deng Wei Ding Yong Liang Qi Zhang 
supported in part by grants from National Natural Science Foundation of China(21822703 and 31670060 to Q.Z.,21803030 to Y.L.,and 31600398 to W.D.);from the National Key Research and Development Program(2018Y F A0900402 and 2016 Y F A0501302);from Shanghai Key Laboratory of Bioactive Small Molecules(ZDSYS14005)。
Linaridins are a small but growing family of natural products belonging to the ribosomally synthesized and post-translationally modified peptide(RiPP)superfamily.In this study,a genome mining approach led to the ident...
关键词：substrate promiscuity SAM analogue dehydrobutyrine BIOSYNTHESIS lanthipeptide 
SERIneALanine Killer:SPT promiscuity inhibits tumour growth via intra-tumoral deoxysphingolipid production
《Signal Transduction and Targeted Therapy》2020年第1期219-220,共2页Mattia Falcone Oliver D.K.Maddocks 
O.D.K.M and M.F.are funded by a Cancer Research UK Career Development Fellowship(C53309/A19702).
In a recent article in Nature,Muthusami et al.1 highlight the promiscuity of serine palmitoyltransferase(SPT)for non-essential amino acids under low serine conditions,illustrating a previously unappreciated mechanism ...
关键词：KILLER SPT TUMOUR 
Enzymatic biosynthesis of benzylisoquinoline alkaloid glycosides via promiscuous glycosyltransferases from Carthamus tinctorius被引量：5
《Chinese Chemical Letters》2019年第2期443-446,共4页Yujiao Zhang Kebo Xie Aijing Liu Ridao Chen Dawei Chen Lin Yang Jungui Dai 
financially supported by the National Natural Science Foundation of China (No. 81573317);CAMS Innovation Fund for Medical Sciences(Nos. CIFMS-2016-I2M-3-012 and CIFMS-2016-I2M-2-002)
Enzymatic glycosylation catalyzed by glycosyltransferases (GTs) has great potential in creating diverse novel and bioactive glycosides. Herein, three new GTs (UGT84 A33, UGT71 AE1 and UGT90 A14) from Carthamus tinctor...
关键词：GLYCOSYLTRANSFERASE Catalytic PROMISCUITY Benzylisoquinoline alkaloids CARTHAMUS tinctorius 
Application of Enzymatic Promiscuity in Pharmaceutical Synthesis:Papain-catalyzed One-pot Synthesis of 1,4-Dihydropyridine Calcium Channel Antagonists and Derivatives被引量：2
《Chemical Research in Chinese Universities》2019年第1期21-25,共5页JIANG Ling YE Wenting SU Weike YU Chuanming 
the National Natural Science Foundation of China(No.21706236);the China Postdoctoral Science Foundation (No.2016M592012);the Foundation for Selected Postdoctoral Project of Zhejiang Province,China(No.BSH1502150).
A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP)calcium channel antagonists felodipme, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde,methyl acetoacetate an...
关键词：PAPAIN Catalytic PROMISCUITY Multicomponent reaction 1 4-DIHYDROPYRIDINE calcium channel ANTAGONIST 
Linux的网络流量监测被引量：1
《网络安全技术与应用》2015年第4期10-11,共2页赵伟光 
本文旨在介绍基于Linux的网络流量监测系统,本系统是一个基于TCP/IP协议的网络应用程序,它提供了一个能够对局域网内部网络数据流量的详尽统计的有用工具,为网络管理提供了重要手段。其使用对象为各学校、科研单位、政府部门、公司企业...
关键词：PROMISCUITY PF_PACKET SOCK_RAW 
Endocrine correlates of mate choice and promiscuity in females of a socially monogamous avian mating system with alternative male reproductive phenotypes被引量：1
《Current Zoology》2014年第6期804-815,共12页Hubert SCHWABL Willow R. LINDSAY Douglas G. BARRON Michael S. WEBSTER 
Acknowledgement We sincerely appreciate the commendable field efforts of a large number of field technicians who assisted with data collection during the course of this study, as well as logistical support provided by B. Congdon, T. Daniel, J. Lindsay and D. Westcott. We also thank members of the Schwabl and Webster labs for their valuable input throughout. Thanks also to Becca Sail＇an and Maren Vitousek for the invitation to contribute to this volume. This research was conducted with appropriate permits and permissions from the governments of Queensland and Australia, and material is based upon work supported by the National Science Foundation （USA） through grants to MSW and HS and a graduate traineeship to DGB.
While our understanding of male reproductive strategies is informed by extensive investigations into endocrine mechanisms, the proximate mechanisms by which females compete for mates and adjust reproduction to social ...
关键词：ANDROGEN Estrogen GLUCOCORTICOID Mate choice PROMISCUITY Alternative phenotypes 
Enzymatic Promiscuity： ＂Amano＂ Lipase AS-catalysed Synthesis of Naphthopyran Derivatives in Anhydrous Media被引量：1
《Chemical Research in Chinese Universities》2014年第3期396-399,共4页JIANG Ling YU Hongwei 
Supported by the Program for Zhejiang Leading Team of Science ＆ Technology Innovation, China（No.2011R50007）, the National Natural Science Foundation of China（Nos.21176215, 21176102） and the Outstanding Young Scholar Grant of Zhejiang University, China（No.R4110092）.
＂Amano＂ lipase AS（lipase from Aspergillus niger）, which naturally hydrolyzes triglycerides, was found promiscuously to catalyze multi-component reactions of aromatic aldehydes with malononitrile and β-naphthol to...
关键词：＂Amano＂ lipase AS Catalytic promiscuity Multi-component reaction Naphthopyran derivative 
Enzymatic Promiscuity： Escherichia coli BioH Esterase-catalysed Aldol Reaction and Knoevenagel Reaction被引量：4
《Chemical Research in Chinese Universities》2014年第2期289-292,共4页JIANG Ling YU Hongwei 
Supported by the National Natural Science Foundation of China（No.21176215）.
Esterase BioH,which is obligatory for biotin synthesis in Escherichia coli,was found to exhibit a promiscuous ability to catalyse Aldol and Knoevenagel reactions with moderate to good yields.The reaction conditions in...
关键词：Escherichia coli BioH esterase Catalytic promiscuity Aldol reaction Knoevenagel reaction 
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