GLYCOSYLTRANSFERASE

作品数：52被引量：161H指数：7
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相关领域：生物学农业科学更多>>
相关作者：刘学群王春台谭艳平王凤山陈宇星更多>>
相关机构：中南民族大学中国科学技术大学山东大学华东师范大学更多>>
相关期刊：《Chemical Research in Chinese Universities》《Beverage Plant Research》《Plant Communications》《Medicinal Plant Biology》更多>>
相关基金：国家自然科学基金北京市自然科学基金国家教育部博士点基金国家高技术研究发展计划更多>>
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Population-scale variability of the human UDP-glycosyltransferase gene family
《Journal of Genetics and Genomics》2024年第11期1228-1236,共9页Daianna González-Padilla Mahamadou D.Camara Volker M.Lauschke Yitian Zhou 
support from the Swedish Research Council(grant numbers 2021-02801 and 2023-03015);Cancerfonden(grant23-0763 PT);by the SciLifeLab and Wallenberg National Program for Data-Driven Life Science(grant WASPDDLS22:006);the Robert Bosch Foundation,Stuttgart,Germany and from the National Autonomous University of Mexico(UNAM)DGECI program Initiation to Research 2023;supported in part by the South African Medical Research Council(SAMRC)。
Human UDP-glycosyltransferases(UGTs)are responsible for the glycosylation of a wide variety of endogenous substrates and commonly prescribed drugs.Different genetic polymorphisms in UGT genes are implicated in interin...
关键词：UDP-Glycosyltransferases Genetic variants POPULATIONS Drug response Cancer risk PHARMACOGENOMICS 
The ZmHSF08-ZmUGT92A1 module regulates heat tolerance by altering reactive oxygen species levels in maize被引量：1
《The Crop Journal》2024年第5期1437-1446,共10页Hao Li Jing Wang Menglong Li Leiming Wu Wenhui Rao Xiaojian Peng Haiyang Jiang 
supported by the National Key Research and Development Program of China (2021YFF1000301);the National Natural Science Foundation of China (31771805)。
GTs(Glycosyltransferases)are important in plant growth and abiotic stresses.However,its role in maize heat response is far from clear.Here,we describe the constitutively expressed UDP-glycosyltransferase ZmUGT92A1,whi...
关键词：Heat shock transcription factors Heat stress Oxidative damage Uridine diphosphate glycosyltransferase Zea mays L. 
Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity
《Acta Pharmaceutica Sinica B》2024年第9期4149-4163,共15页Xinyun Jian Cheng Wang Shijuan Wu Guo Sun Chuan Huang Chengbing Qiu Yuanzheng Liu Peter FLeadlay Dong Liu Zixin Deng Fuling Zhou Yuhui Sun 
the National Key R&D Program of China(2018YFA0903200);the Funds for International Cooperation and Exchange of the National Natural Science Foundation of China(31920103001).
Aminoglycosides(AGs)are a class of antibiotics with a broad spectrum of activity.However,their use is limited by safety concerns associated with nephrotoxicity and ototoxicity,as well as drug resistance.To address the...
关键词：Antibiotic Aminoglycoside biosynthesis Biosynthetic engineering OTOTOXICITY 
Functional characterization,structural basis,and protein engineering of a rare flavonoid 2′-O-glycosyltransferase from Scutellaria baicalensis被引量：1
《Acta Pharmaceutica Sinica B》2024年第8期3746-3759,共14页Zilong Wang Xueqing Du Guo Ye Haotian Wang Yizhan Liu Chenrui Liu Fudong Li HansÅgren Yang Zhou Junhao Li Chao He De-An Guo Min Ye 
supported by the National Key Research and Development Program of China(No.2023YFA0914100);China National Postdoctoral Program for Innovation Talents(No.BX20220022);National Natural Science Foundation of China(No.82304326);Natural Science Foundation of Anhui Province(No.2008085MC92,China);the National Supercomputer Center(SNIC2022-3-34)at Linköping University(Sweden).
Glycosylation is an important post-modification reaction in plant secondary metabolism,and contributes to structural diversity of bioactive natural products.In plants,glycosylation is usually catalyzed by UDP-glycosyl...
关键词：GLYCOSYLTRANSFERASE Regio-selectivity Crystal structure De-glycosylation Catalytic mechanisms 
O-GlcNAcylation determines the function of the key O-GalNAc glycosyltransferase C1GalT1 in bladder cancer被引量：1
《Acta Biochimica et Biophysica Sinica》2024年第8期1108-1117,共10页Yazhuo Jiang Jinpeng Wu Feng Guan Liang Liang Yili Wang 
supported by the grant from the Science and Technology Development of Shaanxi Province,China(No.2023-YBSF-004).
Protein glycosylation is a type of protein post-translational modification.One specific example is the modification of proteins with O-linkedβ-N-acetylglucosamine(O-GlcNAc)and O-linkedα-N-acetylgalactosamine(O-GalNA...
关键词：C1GalT1 O-GlcNAc modification bladder cancer T antigen 
O-glycosylation of SARS-CoV-2 spike protein by host O-glycosyltransferase strengthens its trimeric structure被引量：1
《Acta Biochimica et Biophysica Sinica》2024年第8期1118-1129,共12页Zhijue Xu Han Zhang Jiaqi Tian Xin Ku Rumeng Wei Jingli Hou Can Zhang Fang Yang Xia Zou Yang Li Hiroyuki Kaji Sheng-Ce Tao Atsushi Kuno Wei Yan Lin-Tai Da Yan Zhang 
supported by the grants from Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University(No.21TQ1400210);the National Natural Science Foundation of China(Nos.32371332,32071271,and 22007065);the Fundamental Research Funds for the Central Universities(No.KLSB2023KF-04).
Protein O-glycosylation,also known as mucin-type O-glycosylation,is one of the most abundant glycosylation in mammalian cells.It is initially catalyzed by a family of polypeptide GalNAc transferases(ppGalNAc-Ts).The t...
关键词：O-GLYCOSYLATION SARS-CoV-2 spike protein GLYCOSYLTRANSFERASE ppGalNAc-T 
The UDP-glycosyltransferase OsUGT706D2 positively regulates cold and submergence stress tolerance in rice
《The Crop Journal》2024年第3期732-742,共11页Qing Liu Lanlan Zhang Shuwei Lyu Hang Yu Wenjie Huang Liqun Jiang Jing Zhang Bingrui Sun Xingxue Mao Pingli Chen Junlian Xing Wenfeng Chen Zhilan Fan Shijuan Yan Chen Li 
jointly funded by National Natural Science Foundation of China(32372206);the Natural Science Foundation of Guangdong Province(2023A1515030224,2023A0505090005,2021TQ06N115);the Governor’s Special Program of 2023(Yuecainong[2023]No.145);the Key Field Research and Development Project of Guangdong Province(2022B0202110003);the Special Fund for Scientific Innovation Strategy-Construction of High Level Academy of Agriculture Science(R2020PY-JX001);Guangdong Key Laboratory of New Technology in Rice Breeding(2023B1212060042)。
In a genome-wide association study,we identified a rice UDP-glycosyltransferase gene,OsUGT706D2,whose transcription was activated in response to cold and submergence stress and to exogenous abscisic acid(ABA).OsUGT706...
关键词：UDP-glycosyltransferase RICE Cold tolerance Submergence tolerance ABA 
A multi-enzymatic cascade reaction for the synthesis of bioactive C-oligosaccharides
《Chinese Chemical Letters》2024年第6期451-455,共5页Kebo Xie Qian Zhang Fei Ye Jungui Dai 
financially supported by the National Key Research and Development Program of China(No.2020YFA0908000);CAMS Innovation fund for Medical Sciences(No.2021-I2M-1–029)。
C-Oligosaccharides are rare in nature and possess diverse bioactivities.However,their chemical synthesis faces many challenges.In this work,enzymatic introduction of C-linked sugar chains to target aglycones was succe...
关键词：C-Oligosaccharides C-Glycosyltransferase Cyclomaltodextrin glucanotransferase GLUCOAMYLASE Enzymatic synthesis SGLT2 inhibitory activity 
Rational design of a highly active N-glycosyltransferase mutant using fragment replacement approach
《Engineering Microbiology》2024年第1期10-17,共8页Jiangyu Yang Kun Li Yongheng Rong Zhaoxi Liu Xiaoyu Liu Yue Yu Wenjing Shi Yun Kong Min Chen 
supported by the National Key R&D Program of China(2022YFA1304103);the National Natural Science Foundation of China(Grant numbers 32070921);the Key Research and Develop Program of Shandong Province(grant number 2020CXGC010601);Taishan industry leading talents project(No.tscy20200221).
The modularity of carbohydrate-active enzymes facilitates that enzymes with different functions have similar fragments.However,because of the complex structure of the enzyme active sites and the epistatic effects of v...
关键词：N-glycosyltransferase Computational design GLYCOPROTEIN Fragment replacement GT41 
Computational-guided discovery of UDP-glycosyltransferases for lauryl glucoside production using engineered E.coli
《Bioresources and Bioprocessing》2024年第1期1340-1352,共13页Kasimaporn Promubon Kritsada Tathiya Aussara Panya Wasu Pathom-Aree Pachara Sattayawat 
This work(Grant No.RGNS 64-069)was financially supported by Office of the Permanent Secretary,Ministry of Higher Education,Science,Research and Innovation;partially supported by Chiang Mai University.
Defining suitable enzymes for reaction steps in novel synthetic pathways is crucial for developing microbial cell factories for non-natural products.Here,we developed a computational workflow to identify C12 alcohol-a...
关键词：UDP-glycosyltransferase Lauryl glucoside Computational method 1-Dodecanol Engineered E.coli Novel biosynthetic pathway Genome mining 
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