O-GLYCOSYLATION

作品数：19被引量：31H指数：2
导出分析报告
相关领域：生物学更多>>
相关作者：张宏廖凯俊李中军孟祥豹李庆更多>>
相关机构：北京大学中国科学院更多>>
相关期刊：《Journal of Biomedical Research》《Frontiers of Medicine》《Frontiers of Chemical Science and Engineering》《Science China(Life Sciences)》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
TAZ inhibits SCLC metastasis through GALNT18-mediated O-glycosylation
《Journal of Genetics and Genomics》2024年第11期1314-1317,共4页Zhiwei Zhang Zhijue Xu Xinyi Qian Yanxu Chen Duo Li Zhen Qin Luonan Chen Yan Zhang Yujuan Jin Hongbin Ji 
supported by the National Key Research and Development Program of China(grants 2022YFA1103900,2020YFA0803300 to H.J.;2022YFA1004800 to L.C.);the National Natural Science Foundation of China(grants 82341002,32293192,82030083 to H.J.;82273400 to Y.J.;82303039 to Z.Q.;32071271 to Y.Z.;T2350003,T2341007,12131020,31930022 to L.C.);the Innovative Research Team of High-level Local Universities in Shanghai(SSMU-ZLCX20180500 to H.J.);Science and Technology Commission of Shanghai Municipality(23JS1401300 to L.C.);the Japan Science and Technology Agency Moonshot R&D(JPMJMS2021 to L.C.)。
Small cell lung cancer(SCLC)is a recalcitrant cancer featured with high metastasis capability.We previously found that TAZ acts as a crucial molecular switch in orchestrating SCLC phenotypic transition and metastasis(...
关键词：METASTASIS SCLC 
O-glycosylation of SARS-CoV-2 spike protein by host O-glycosyltransferase strengthens its trimeric structure被引量：1
《Acta Biochimica et Biophysica Sinica》2024年第8期1118-1129,共12页Zhijue Xu Han Zhang Jiaqi Tian Xin Ku Rumeng Wei Jingli Hou Can Zhang Fang Yang Xia Zou Yang Li Hiroyuki Kaji Sheng-Ce Tao Atsushi Kuno Wei Yan Lin-Tai Da Yan Zhang 
supported by the grants from Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University(No.21TQ1400210);the National Natural Science Foundation of China(Nos.32371332,32071271,and 22007065);the Fundamental Research Funds for the Central Universities(No.KLSB2023KF-04).
Protein O-glycosylation,also known as mucin-type O-glycosylation,is one of the most abundant glycosylation in mammalian cells.It is initially catalyzed by a family of polypeptide GalNAc transferases(ppGalNAc-Ts).The t...
关键词：O-GLYCOSYLATION SARS-CoV-2 spike protein GLYCOSYLTRANSFERASE ppGalNAc-T 
Genetic variants in C1GALT1 are associated with gastric cancer risk by influencing immune infiltration被引量：2
《Journal of Biomedical Research》2024年第4期348-357,共10页Mengfan Guo Jingyuan Liu Yujuan Zhang Jingjing Gu Junyi Xin Mulong Du Haiyan Chu Meilin Wang Hanting Liu Zhengdong Zhang 
funded by the National Key R&D Program of China(Grant Nos.2018YFC1313100 and 2018YFC1313102);the National Natural Science Foundation of China(Grant No.81773539);Collaborative Innovation Center for Cancer Personalized Medicine;the Priority Academic Program Development of Jiangsu Higher Education Institutions(Public Health and Preventive Medicine).
Core 1 synthase glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase 1(C1GALT1)is known to play a critical role in the development of gastric cancer,but few studies have elucidated associations between geneti...
关键词：O-GLYCOSYLATION genetic variants immune status gastric cancer 
O-glycosylation in viruses:A sweet tango被引量：1
《mLife》2024年第1期57-73,共17页Annan Ming Jianxin Zhao Yihan Liu Yibo Wang Xiaohui Wang Jing Li Leiliang Zhang 
supported by the grants from the National Natural Science Foundation of China(32271285,31872720,82272306,and 82072270);the R&D Program of Beijing Municipal Education Commission(KZ202210028043);the Taishan Scholars Program(tstp20221142);the Academic Promotion Program of Shandong First Medical University(2019LJ001);the Beijing National LaboratorfyorMolecular Sciences(BNLMS202108);the Chinese Academy of Sciences Pioneer Hundred Talents Program.
O-glycosylation is an ancient yet underappreciated protein posttranslational modification,on which many bacteria and viruses heavily rely to perform critical biological functions involved in numerous infectious diseas...
关键词：immune response O-GalNAc O-GLCNAC O-GLYCOSYLATION virus 
Hydrogen bond-assisted 1,2-cis O-glycosylation under mild hydrogenolytic conditions被引量：1
《Chinese Chemical Letters》2023年第4期313-317,共5页Gefei Li Yanlong Luo Juan Mo Masato Noguchi Jie Jing Zhenyang Luo Shin-ichiro Shoda Xin-Shan Ye 
financially supported by the State Key Laboratory of Natural and Biomimetic Drugs (No. K202216);the National Natural Science Foundation of China (Nos. 21907004 and 81821004);the National Key R&D Program of China (No.2018YFA0507602);the Beijing Outstanding Young Scientist Program(No. BJJWZYJH01201910001001);a Grant-in-Aid for Scientific Research from the Ministry of Education,Culture,Sports,Science and Technology,Japan。
A hydrogen bond-assisted α-selective glycosylation reaction by using 4,6-dibenzyloxy-1,3,5-triazin-2-yl(DBT) β-glycosyl donors was developed for the efficient construction of 1,2-cis-α-glycosidic bond in natural pr...
关键词：O-GLYCOSYLATION Hydrogen bond α-Selectivity GLYCOLIPID Natural product 
Self-assembled hexameric capsule:A highlyβ-selective O-glycosylation reaction enabled via proton wire mechanism
《Green Synthesis and Catalysis》2023年第1期7-9,共3页Kuppusamy Kanagaraj Julius Rebek Jr. Yang Yu 
This work was supported by the National Natural Science Foundation of China(Nos.22071144 and 21801164);by Shanghai Scientific and Technological Committee(No.22010500300).
A simple methodology has been developed for the synthesis of highlyβ-selective O-glycosylation scaffolds of wider substrate scope under mild conditions using a self-assembled hexameric capsule.The reaction conditions...
关键词：CAPSULE Self-assembly β-Selective glycosylation Synthetic receptor Proton wire mechanism 
The group of Professor Suwei Dong have made progress in the study of the mechanism of O-glycosylation modification regulating the aggregation of Amyloid-β
《Journal of Chinese Pharmaceutical Sciences》2021年第12期1008-1009,共2页无 
近日,学术期刊《Journal of the American Chemical Society》在线发表了北京大学药学院天然药物及仿生药物国家重点实验室董甦伟团队题为"O-Glycosylation Induces Amyloid-β to Form New Fibril Polymorphs Vulnerable for Degradati...
关键词：学术期刊 北京大学药学院 聚集机制 糖基化修饰 聚集体 团队 
O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an “O-Follow-N” rule被引量：16
《Cell Research》2021年第10期1123-1125,共3页Wenmin Tian Delin Li Nan Zhang Guijie Bai Kai Yuan Haixia Xiao Feng Gao Yang Chen Catherine C.L.Wong George Fu Gao 
We would like to thank Min Huang, Yue Zhou, Guanbo Wang, Minjie Tan for their assistance in mass spectrometry experiments. We would also like to thank Thermo Fisher Scientific for their support in collaboration. We would like to thank Shuaixin Gao, Yu Hu, Chao Su, Qihui Wang for their assistance in S protein purification. We thank Hui Wang and Beijing Institute of Biological Products Co., Ltd. for providing SARS-CoV-2 virions. We are grateful to Xuefei Yin (PMI Inc.), Yan Zhang, Wenfeng Zeng and Mingliang Ye for the assistance in the use of the software. We thank Yan Zhang and Xin Chen for their insightful discussion. This work was supported by the Fundamental Research Funds for the Central Universities (BMU2017YJ003, BMU2018XTZ002);the Research Funds from Health@InnoHK Program launched by the Innovation Technology Commission of the Hong Kong Special Administrative Region, the PKU-Baidu Fund (2019BD007);the Training Program of the Big Science Strategy Plan (2020YFE0202200);the National Program on Key Research Projects of China (2016YFD0500301);the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project (TSBICIP-KJGG-004).
Dear Editor,Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),emerged in late 2019 and has since caused a pandemic.Although there have been extensive...
关键词：PATTERN acute RESPIRATORY 
OGP: A Repository of Experimentally Characterized O-glycoproteins to Facilitate Studies on O-glycosylation
《Genomics, Proteomics & Bioinformatics》2021年第4期611-618,共8页Jiangming Huang Mengxi Wu Yang Zhang Siyuan Kong Mingqi Liu Biyun Jiang Pengyuan Yang Weiqian Cao 
supported by grants from the National Key R&D Program of China(Grant Nos.2018YFC0910300,2016YFA0501303,and 2016YFB0201702);the National Natural Science Foundation of China(Grant No.91853102);the innovative research team of high-level local university in Shanghai。
Numerous studies on cancers, biopharmaceuticals, and clinical trials have necessitated comprehensive and precise analysis of protein O-glycosylation. However, the lack of updated and convenient databases deters the st...
关键词：O-GLYCOSYLATION O-glycoprotein repository Site prediction O-glycoprotein related website Data mining 
Clinic implication of MUC1 O-glycosylation and C1GALT1 in esophagus squamous cell carcinoma被引量：4
《Science China(Life Sciences)》2018年第11期1389-1395,共7页Yuming Wang Xiaodong Liao Qing Ye Lei Huang 
supported by the National Natural Science Foundation of China (81472461)
Esophagus squamous cell carcinoma(ESCC) is one of the most aggressive malignant tumors in the world. Our previous data demonstrates that oncoprotein MUC1 is related with metastasis and poor outcome of ESCC. However, a...
关键词：MUC1 gene mutation GLYCOSYLATION CIGALT1 ESCC 
全选清除导出
共2页<12>
检索报告 对象比较 聚类工具 使用帮助 返回顶部