OGP: A Repository of Experimentally Characterized O-glycoproteins to Facilitate Studies on O-glycosylation  

作　　者：Jiangming Huang Mengxi Wu Yang Zhang Siyuan Kong Mingqi Liu Biyun Jiang Pengyuan Yang Weiqian Cao 

机构地区：[1]Department of Chemistry and Institutes of Biomedical Sciences,Fudan University,Shanghai 200032,China [2]The Fifth People’s Hospital,Fudan University,and the Shanghai Key Laboratory of Medical Epigenetics,the International Co-laboratory of Medical Epigenetics and Metabolism,Ministry of Science and Technology,Fudan University,Shanghai 200032,China [3]NHC Key Laboratory of Glycoconjugates Research(Fudan University),Shanghai 200032,China

出　　处：《Genomics, Proteomics & Bioinformatics》2021年第4期611-618,共8页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by grants from the National Key R&D Program of China(Grant Nos.2018YFC0910300,2016YFA0501303,and 2016YFB0201702);the National Natural Science Foundation of China(Grant No.91853102);the innovative research team of high-level local university in Shanghai。

摘　　要：Numerous studies on cancers, biopharmaceuticals, and clinical trials have necessitated comprehensive and precise analysis of protein O-glycosylation. However, the lack of updated and convenient databases deters the storage of and reference to emerging O-glycoprotein data. To resolve this issue, an O-glycoprotein repository named OGP was established in this work.It was constructed with a collection of O-glycoprotein data from different sources. OGP contains 9354 O-glycosylation sites and 11,633 site-specific O-glycans mapping to 2133 O-glycoproteins, and it is the largest O-glycoprotein repository thus far.Based on the recorded O-glycosylation sites, an O-glycosylation site prediction tool was developed. Moreover, an OGP-based website is already available(http://www.oglyp.org/). The website comprises four specially designed and user-friendly modules:statistical analysis, database search, site prediction, and data submission. The first version of OGP repository and the website allow users to obtain various O-glycoprotein-related information, such as protein accession Nos., O-glycosylation sites,O-glycopeptide sequences, site-specific O-glycan structures, experimental methods, and potential O-glycosylation sites.O-glycosylation data mining can be performed efficiently on this website, which will greatly facilitate related studies. In addition, the database is accessible from OGP website(http://www.oglyp.org/download.php).

关 键 词：O-GLYCOSYLATION O-glycoprotein repository Site prediction O-glycoprotein related website Data mining 

分 类 号：Q51[生物学—生物化学]