O-glycosylation in viruses:A sweet tango  

作　　者：Annan Ming Jianxin Zhao Yihan Liu Yibo Wang Xiaohui Wang Jing Li Leiliang Zhang 

机构地区：[1]Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,China [2]Medical Science and Technology Innovation Center,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan,China [3]Bejing Key Laboratory of DNA Damage Response and College of Life Sciences,Capital Normal University,Beijing,China [4]Laboratory of Chemical Biology,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,China [5]School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei,China [6]Bejing National Laboratory for Molecular Sciences,Beijing,China

出　　处：《mLife》2024年第1期57-73,共17页微生物（英文）

基　　金：supported by the grants from the National Natural Science Foundation of China(32271285,31872720,82272306,and 82072270);the R&D Program of Beijing Municipal Education Commission(KZ202210028043);the Taishan Scholars Program(tstp20221142);the Academic Promotion Program of Shandong First Medical University(2019LJ001);the Beijing National LaboratorfyorMolecular Sciences(BNLMS202108);the Chinese Academy of Sciences Pioneer Hundred Talents Program.

摘　　要：O-glycosylation is an ancient yet underappreciated protein posttranslational modification,on which many bacteria and viruses heavily rely to perform critical biological functions involved in numerous infectious diseases or even cancer.But due to the innate complexity of O-glycosylation,research techniques have been limited to study its exact role in viral attachment and entry,assembly and exit,spreading in the host cells,and the innate and adaptive immunity of the host.Recently,the advent of many newly developed methodologies(e.g.,mass spectrometry,chemical biology tools,and molecular dynamics simulations)has renewed and rekindled the interest in viral-related O-glycosylation in both viral proteins and host cells,which is further fueled by the COVID-19 pandemic.In this review,we summarize recent advances in viral-related O-glycosylation,with a particular emphasis on the mucin-type O-linkedα-N-acetylgalactosamine(O-GalNAc)on viral proteins and the intracellular O-linkedβ-N-acetylglucosamine(O-GlcNAc)modifications on host proteins.We hope to provide valuable insights into the development of antiviral reagents or vaccines for better prevention or treatment of infectious diseases.

关 键 词：immune response O-GalNAc O-GLCNAC O-GLYCOSYLATION virus 

分 类 号：R37[医药卫生—病原生物学]