美沙拉嗪联合复方谷氨酰胺治疗急性放射性肠炎的疗效观察  

Effect of mesalazine combined with compound glutamine in the treatment of acute radiation enteritis

作　　者：唐美月 陈威[1] 曹硕[1] 王思亮[1] Tang Meiyue;Chen Wei;Cao Shuo;Wang Siliang(Department of Medical Oncology,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院肿瘤科,沈阳110021

出　　处：《中国医师进修杂志》2019年第2期124-126,共3页Chinese Journal of Postgraduates of Medicine

基　　金：辽宁省自然科学基金指导计划(201602863).

摘　　要：目的评估美沙拉嗪联合复方谷氨酰胺治疗放射性肠炎的效果。方法将94例患者按随机数字表法分为观察组和治疗组,每组47例,对照组给予复方谷氨酰胺口服治疗,观察组在复方谷氨酰胺的基础上,加用美沙拉嗪口服治疗。治疗后按照急性放射性损伤分级标准(RTOG)比较疗效,肿瘤患者生命质量评分(QOL)评估生命质量的改善。结果观察组患者的总有效率为95.7%(45/47),对照组为78.7%(37/47),两组比较差异有统计学意义(P<0.05)。在放射治疗结束时,观察组患者表现出显著的生命质量优势(P<0.05)。结论美沙拉嗪联合复方谷氨酰胺治疗放射性肠炎具有优势,并可改善生命质量。Objective To evaluate the efficacy of mesalazine combined with compound glutamine in the treatment of radiation related enteritis.Methods Ninety-four patients were randomly divided into the observation group and the treatment group,with 47 cases in each group. Patients in control group were given compound glutamine orally. On the basis of compound glutamine,patients in the observation group was added mesalazine orally. Before and after treatment,all patients were assessed according to acute radiation injury grading (RTOG),and the quality of life (QOL) scale for cancer patients was used to evaluate the improvement of quality of life.Results The total effective rate of the observation group was 95.7%(45/47),and that of the control group was 78.7%(37/47).The difference was statistically significant (P<0.05). At the end of radiation therapy,patients in the observation group showed significant superiority in quality of life (P<0.05).Conclusions Mesalazine combined with compound glutamine in the treatment of radiation-associated enteritis has advantages and can improve the quality of life.

关 键 词：放射性肠炎 美沙拉嗪 复方谷氨酰胺 

分 类 号：R730.55[医药卫生—肿瘤]