基于Ualcan数据库分析caspase-7在结肠癌中的表达和意义  

Ualcan-based analysis of caspase-7 expression and prognostic role in colon cancer

作　　者：闫兆鹏[1] 王睿[2] 苏琪[1] Yan Zhaopeng;Wang Rui;Su Qi(Department of Eighth General Surgery/Department of Anorectum and Anus Surgery,Shengjing Hospital of China Medical University,Shenyang 110004,China;Department of Critical Care Medicine,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院第八普通外科/结直肠肛门病外科,沈阳110004 [2]中国医科大学附属盛京医院重症医学科,沈阳110004

出　　处：《中国医师进修杂志》2019年第2期158-160,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的通过Ualcan数据库探讨caspase-7(CASP7)在结肠癌中的表达和意义。方法统计Ualcan数据库中CASP7在结肠癌中的表达情况并进行生存分析,通过Oncolnc数据库对得出的结果进行验证。并分析CASP7与KRAS基因和TP53I3基因的协同表达情况。结果在结肠癌中,CASP7的表达较低,且低表达者的预后劣于高表达者。CASP7与KRAS基因和TP53I3基因存在共表达。结论CASP7在结肠癌中存在低表达且与不良预后相关。Objective To discuss the expression of caspase-7 (CASP7) and its prognostic role in colon cancer.Methods CASP7 expression data was retrieved from Ualcan database,and the survival data of CASP7 down-regulated colon cancer patients was retrieved from Ualcan database and Oncolnc database.Results In colon cancer,the expression of CASP7 was down-regulated and indicated a relatively worse prognosis. The expression of CASP7 was correlated with KRAS and TP53I3.Conclusions CASP7 is down-regulated in colon cancer and indicates a worse prognosis.

关 键 词：结肠癌 CASPASE-7 Ualcan数据库 

分 类 号：R735.35[医药卫生—肿瘤]