低氧诱导的miR-210在非小细胞肺癌中预后价值的探讨  

Study on the prognostic value of hypoxic-induced miR-210 in non-small cell lung cancer

作　　者：陈瑞琳[1] 武润苗 吴桦[1] 杨淑梅[1] Chen Ruilin;Wu Runmiao;Wu Hua;Yang Shumei(Department of Respiratory and Critical Care Medicine,Shaanxi Provincial People's Hospital, Xi'an 710000,China)

机构地区：[1]陕西省人民医院呼吸与危重症医学科,西安710000

出　　处：《国际呼吸杂志》2019年第2期101-106,共6页International Journal of Respiration

摘　　要：目的调查microRNA-210(miR-210)在非小细胞肺癌(NSCLC)患者中的预后价值。方法本研究使用逆转录-聚合酶链反应检测了从2011年1月到2012年3月在陕西省人民医院胸外科接受手术治疗的NSCLC患者的新鲜组织标本中miR-210表达,统计分析miR-210表达与全组患者、肺腺癌和鳞状细胞癌之间的临床因素之间的关系;分析miR-210表达差异和全部患者及其肺腺癌患者的无瘤生存率和总生存率之间的关系。结果在NSCLC中,miR-210高表达患者比miR-210低表达患者的无瘤生存率更低(χ^2=8.119,P<0.01),总生存率更短(χ^2=7.914,P<0.01);在肺腺癌中,miR-210高表达组患者比miR-210低表达组的无瘤生存率更低(RR=2.181,P<0.01),总生存率更短(RR=1.978,P<0.01);miR-210表达与病理分期、淋巴结转移和疾病复发(P<0.05)显著性相关。Cox多因素分析显示,miR-210表达为总生存率的独立预后因素(RR=1.978,P<0.05)。结论miR-210在NSCLC患者,高表达特别是与肺腺癌的患者预后显著相关。miR-210可能为肺腺癌患者预后的生物标志物。Objective To investigate the prognostic value of microRNA-210 (miR-210) in patients with non-small cell lung cancer (NSCLC).Methods In this study, the expression of miR-210 in fresh tissue samples from NSCLC patients undergoing surgery in our hospital from January 2011 to March 2012 was detected by reverse transcriptase polymerase chain reaction (RT-PCR). The relationship between miR-210 expression and clinical factors in the whole group of patients, lung adenocarcinoma and squamous cell carcinoma.Analysis of miR-210 expression differences and relationship between diseases-free and overall survival in all patients and those of lung adenocarcinoma.Results In NSCLC, patients with lower miR-210 expression had lower disease-free survival (χ^2=8.119, P<0.01) and lower overall survival (χ^2=7.914, P<0.01) than patients with low miR-210 expression.In the miR-210 high expression group, the disease-free survival rate was lower in the low-expression group than in the miR-210 group (P<0.01), and the overall survival rate was shorter (P<0.01);miR-210 expression and pathological stage, lymph node metastasis and disease relapse (RR=2.181, P<0.01) were significantly related.Cox multivariate analysis showed that miR-210 expression was an independent prognostic factor for overall survival (RR=1.978, P<0.05).Conclusions High expression of miR-210 is significantly associated with the prognostic of NSCLC patients, especially those with adenocarcinoma.MiR-210 may be a biomarker for prognosis of lung adenocarcinoma patients.

关 键 词：癌 非小细胞肺 MIR-210 肺腺癌 

分 类 号：R734.2[医药卫生—肿瘤]