S100A9蛋白在肠型胃癌组织中的表达及其临床意义  

The expression and clinical significance of S100A9 protein in gastric cancer of intestinal type

作　　者：周荣健[1] 张恒[1] 束平[1] 王洪山[1] 沈振斌[1] 刘凤林[1] 秦净[1] Zhou Rongjian;Zhang Heng;Shu Ping;Wang Hongshan;Shen Zhenbin;Liu Fenglin;Qin Jing(Department of General Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院普通外科,上海200032

出　　处：《中华普通外科杂志》2019年第1期53-57,共5页Chinese Journal of General Surgery

基　　金：中山医院科研发展基金(2016ZSFZ60);上海市科委基金(201540047);上海市浦江人才计划(16PJ1401900).

摘　　要：目的探讨炎性蛋白S100A9在肠型胃癌组织中的表达及其临床意义。方法回顾性分析2008年1至12月复旦大学附属中山医院普通外科收治的278例术后病理诊断为Lauren分型为肠型胃癌的临床病理资料,通过免疫组化方法分析S100A9蛋白在胃癌组织及癌旁组织中的表达情况。结果S100A9蛋白主要在肿瘤间质浸润的炎性细胞中表达。S100A9蛋白高表达与肿瘤浸润深度(P=0.013)、淋巴结转移(P=0.041)、TNM分期相关(P=0.010)。S100A9蛋白高表达组肠型胃癌患者的1、3、5年生存率显著低于低表达组(81.4%、53.9%、47.3%比84.7%、69.3%、60.7%,χ2=4.220,P=0.041)。在TNM分期Ⅲ~Ⅳ期肠型胃癌患者中,S100A9蛋白高表达组1、3、5年生存率显著低于低表达组(χ2=3.861,P=0.049)。在术后化疗患者中,S100A9蛋白高表达肠型胃癌组患者的预后差于低表达组(χ2=5.049,P=0.025)。多因素分析发现,S100A9蛋白表达水平并不是影响肠型胃癌患者预后的独立危险因素(P=0.078)。结论S100A9蛋白高表达的肠型胃癌患者预后较差。Objective To investigate the expression and clinical significance of pro-inflammation S100A9 protein in intestinal type gastric cancer. Methods We retrospectively analyzed the clinicopathological materials of the 278 patients who were diagnosed as Lauren classification intestinal gastric cancer and underwent surgical treatment between January and December 2008 at the Department of General Surgery,Zhongshan Hospital Fudan University.Immunohistochemistry was used to analyze the expression of S100A9 protein in tumor tissues and para-tumor tissues. Results High expression of S100A9 protein was associated with the depth of tumor invasion (P=0.013),lymph node metastasis (81.4%,53.9%,47.3% vs.84.7%,69.3%,60.7%,χ2=4.220,P=0.041) and TNM stage (P=0.010).The overall survival rate of these patients with high expression of S100A9 protein was significantly lower than those with low expression of S100A9 protein.In stage Ⅲ/Ⅳ patients,the overall survival rate of these patients with high expression of S100A9 protein was significantly lower than those with low expression of S100A9 protein.Moreover,for those patients who received postoperative chemotherapy,the prognosis of the patients with high expression of S100A9 protein was poorer than those with low expression.By multivariable analysis,the expression of S100A9 protein was not an independent risk factor for the prognosis of intestinal gastric cancer patients. Conclusions High expression of S100A9 protein in intestinal gastric cancer was associated with poor prognosis.

关 键 词：胃肿瘤 存活率 预后 炎症 

分 类 号：R735.2[医药卫生—肿瘤]