聚乙二醇200溶剂中镍催化合成喹唑啉酮衍生物  

Nickel-Catalyzed Synthesis of Quinazolinone Derivatives in Polyethylene Glycol 200

作　　者：许贻文 张鹏 刘彩琴[1] 林晨[1] 林小燕[1] 柯方[1] Xu Yiwen;Zhang Peng;Liu Caiqin;Lin Chen;Lin Xiaoyan;Ke Fang(Department of Pharmacy, Fujian Medical University, Fuzhou 350004)

机构地区：[1]福建医科大学药学院

出　　处：《有机化学》2019年第2期538-543,共6页Chinese Journal of Organic Chemistry

基　　金：福建省自然科学基金(Nos.2016J01686,2016J01372,2016Y9051,2017J01820);福建医科大学基金(No.2015MP008)资助项目~~

摘　　要：以廉价、易得的氯化镍与脯氨酸锂为催化剂,在聚乙二醇200(PEG 200)溶剂中建立一种操作简单、经济环保的2-卤代苯甲酸和脒类盐酸盐合成喹唑啉酮衍生物的方法.该方法具有操作简便、无毒和无刺激的特点,均能以较高的产率得到一系列喹唑啉酮类衍生物,最高产率达94%.A simple and economic method for synthesizing quinazolinones from substituted 2-halobenzoic acids and amidines was developed by nickel-catalysis in wet polyethylene glycol 200 (PEG 200) as an eco-friendly medium. The present methodology is operationally simple, non-toxic and non-irritative, and varieties of quinazolinone derivatives were obtained in high yields of up to 94%.

关 键 词：聚乙二醇(PEG 200) 喹唑啉酮 氯化镍 2-卤代苯甲酸 脒盐 

分 类 号：O621.251[理学—有机化学]