顺铂联合化疗治疗卵巢恶性生殖细胞肿瘤  

Cisplatin-Based Chemotherapy in the Management of Germ Cell Tumors of Ovary

作　　者：张蓉[1] 章文华[1] 吴令英[1] 王桂香[1] 李洪君[1] 李淑敏[1] 洪婉君[1] 刘丽影[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤研究所肿瘤医院妇瘤科,北京市100021

出　　处：《中国肿瘤临床》2002年第3期164-166,170,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨卵巢恶性生殖细胞肿瘤的治疗疗效及复发患者二线治疗。方法:对我院1958年11月～1998年12月312例卵巢恶性肿瘤中的154例接受顺铂方案化疗的卵巢恶性生殖细胞肿瘤结果进行分析。结果:154例卵巢恶性生殖细胞肿瘤的总生存率为74.7%,初治患者(Ⅰ～Ⅲ期)92例,5年生存率为92.2%,其中66例(71.7%)保留生育功能,19例已正常生育20次。复发转移62例,5年生存率51.1%,8例保留生育功能。结论:为了提高卵巢恶性生殖细胞肿瘤生存率,首次手术时应正确分期,术后及时采用当前标准BEP方案作为一线化疗,连续3～6疗程。对复发患者,根据以往治疗情况尽早选用有效的二线方案化疗,有利于提高生存率。Objective:To evaluate the efficacy of cisplatin-based combination chemotherapy in patients with ovarian germ cell tumors and second-line chemotherapy for patients with recur -rent germ cell tumors.Methods:A total of154patients with ovarian germ cell tumors from1985-1998were analysed retrospectively.All patients received cisplatin-based chemotherapy as a part of their first-line or salvage therapy at cancer hospital.Results:The overall5-year survival rate was74.7%and the mean5-year survival rate of patients with stage I-III disease was92.2%and that for the patients with recurrent disease was51.1%.Seventy-four cases preserved fertility,22patients attempted conception after chemotherapy and19of whom were successful.A total of20living births were documented.Conclusion:To improve the prognosis of malignant germ cell tumor of ovary,at initial operation,a comprehensive surgical staging procedure is performed.BEP is the most effective first-line regimen at present.Current patients receive early second-line chemotherapy can increase the survival of patients.

关 键 词：卵巢肿瘤 药物联合治疗 疗效 恶性生殖细胞肿瘤 顺铂 

分 类 号：R737.31[医药卫生—肿瘤] R730.53[医药卫生—临床医学]