大剂量三苯氧胺在肺癌患者体内的药物效应动力学研究  

Study on Pharmacodynamics of High-Dose Tamoxifen in NSCLC Patients

作　　者：陈玲[1] 王亚蓉[2] 李蓉[1] 李毅[1] 李睿[1] 肖菊香[1] 

机构地区：[1]西安交通大学第一医院肿瘤内科,西安市710061 [2]西安交通大学第一医院影像中心

出　　处：《中国肿瘤临床》2002年第3期201-203,共3页Chinese Journal of Clinical Oncology

基　　金：卫生部科学研究基金资助(96-1-250)

摘　　要：目的:进行大剂量三苯氧胺在肺癌患者体内的药效学研究,观察疗效和毒性反应,为进一步临床试验提供依据。方法:随机分两组:30例采用三苯氧胺加化疗,30例单纯化疗。三苯氧胺320mgpod1,160mgpod2～7,化疗方案NVB+CDDP和VP-16+CDDP。间隔21天重复一次,两周期后评价疗效。结果:三苯氧胺加化疗组有效率40%(12/30),化疗组有效率13%(4/30)(P<0.05,χ2=4.1761),有统计学差异,两组毒性无显著性差异。结论:大剂量三苯氧胺与化疗联合应用疗效提高,毒性能耐受,值得扩大临床试验。Objective:To study the pharmacodynamics of high-dose tamoxifen in treatment of non-small cell lung cancer(NSCLC)and observe its effect and adverse reaction to provide the support of further clinical investigation.Methods:In the period of1999to2001,60NSCLC patients were randomized into two groups.Treatment group:Thirty patients received high-dose tamoxifen+chemotherapy(TAM320mg orally d1and160mg orally d2-7plus vinorelbine and cis-platin).The regimen was repeated at21days interval,the other30patients were treated with chemotherapy alone as control,and response was evaluated two weeks later.Results:The effec-tive rate of the treatment group was40%(12/30)while that of the control group was13%(4/30)(P<0.05,χ 2 =4.1761).There was significant difference between these two groups,and the toxic re-action was same statistically.Conclusion:Combination of high-dose tamoxifen and chemothera-py is more better than the control group on effect and the adverse reaction is tolerable.There-fore,high-dose tamoxifen plus chemotherapy can be used for further clinical trial.

关 键 词：三苯氧胺 药物效应动力学 肺癌 化疗 大剂量 研究 

分 类 号：R734.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]