生藤中新甾体皂苷衍生物的结构鉴定  

New steroid glycoside derivatives from Stelmatocrypton khasianum

作　　者：张庆英[1] 吴刚[2] 刘寿养[3] 赵玉英[1] 程铁明[1] 

机构地区：[1]北京大学药学院,北京100083 [2]包头医学院,内蒙古包头014010 [3]广西中医学院,广西南宁530001

出　　处：《中草药》2002年第1期6-8,共3页Chinese Traditional and Herbal Drugs

摘　　要：目的　研究生藤的化学成分。方法　利用各种色谱技术分离纯化 ,通过理化常数测定和波谱方法鉴定其结构。结果　从生藤茎的 95 %Et OH提取物中分离得到 7个化合物 ,其结构经波谱等方法鉴定为 β-谷甾醇 - 3- O- β- D-葡萄糖苷 - 6′- O-二十烷酸酯 ( ) ,2α,3β,2 3-三羟基 -齐墩果 - 12 -烯 - 2 8-酸 ( ) ,2α,3β,2 3-三羟基 -乌苏 - 12 -烯 - 2 8-酸( ) ,β-谷甾醇 - 3- O- β- D-葡萄糖苷 ( ) ,硬脂酸 ( ) ,葡萄糖 ( )和蔗糖 ( )。结论　所有化合物均为首次从该植物中分离得到 ,其中化合物 为 1新化合物。Object To study the chemical constituents of Stelmatocrypton khasianum (Benth.) H. Baill.. Methods Some constituents were isolated by chromatographic methods and identified by physicochemical constants and their structures were elucidated by spectral data. Results Seven compounds were isolated from the stem of S. khasianum and their structures were identified as β-sitosterol-3-O-β-D-glucoside-6′-O-eicosanate (Ⅰ), 2α, 3β, 23-trihydroxy-olean-12-ene-28-oic acid (Ⅱ), 2α, 3β, 23-trihydroxy-urs-12-ene-28-oic acid (Ⅲ), β-sitosterol-3-O-β-D-glucoside (Ⅳ), stearic acid (Ⅴ), glucose (Ⅵ), and sucrose (Ⅶ) respectively. Conclusion All compounds were obtained from this plant for the first time, and compound I is new.

关 键 词：生藤 β-谷甾醇-3-O-β-D-葡萄糖苷-6′-O-二十烷酸酯 新甾体皂苷衍生物 结构 中药 化学成分 

分 类 号：R284.1[医药卫生—中药学]