松果体实质肿瘤病理学及免疫组织化学观察  

Pathological and immunohistochemical study of pineal parenchymal tumors

作　　者：方静宜[1] 罗麟[1] 李敬军[1] 孙淑清[1] 袁艳华[1] 

机构地区：[1]北京市神经外科研究所神经病理室,100050

出　　处：《中华病理学杂志》2002年第1期8-11,共4页Chinese Journal of Pathology

摘　　要：目的　探讨松果体实质肿瘤的组织学分型、分化及其发病和预后的特点。方法　应用HE染色对 2 1例松果体实质肿瘤进行组织学分型 ,对其中 2 0例行突触素、神经元特异性烯醇化酶(NSE)、神经丝蛋白 (NF)、神经母细胞瘤 (NB)、胶质纤维酸性蛋白 (GFAP)、细胞角蛋白 (CK)、结蛋白免疫组织化学SP法染色 ,并进行临床资料分析及随访。结果　 2 1例松果体实质肿瘤标本中 ,松果体细胞瘤 9例 ,松果体母细胞瘤 4例 ,中间分化型松果体实质肿瘤 8例。免疫组织化学染色 :突触素、NSE2 0例阳性 ,NF 14例阳性 ,GFAP 15例阳性 ,NB 2例阳性 ;结蛋白和CK全部阴性。结论　松果体实质肿瘤中明显具有松果体细胞瘤和松果体母细胞瘤两个阶段特点以及具有中间分化、移行特征者应归于中间分化型松果体实质肿瘤 ;该肿瘤可向神经元分化 ,未发现向上皮及肌肉分化 ;术后Objective To investigate the histological typing and differentiation as well as clinical manifestation and prognosis in pineal parenchymal tumors (PPTs). Methods The histological typing of 21 PPTs were made by using HE staining. Synaptophysin (Syn), neuron special enolase (NSE), neurofilament (NF), neuroblastoma (NB), glial fibrillary acid protein (GFAP), cytokeratin (CK), desmin (Des) were detected in 20 cases with SP immunohistochemical staining methods. Analysis of the clinical data and follow up were performed. Results 9 pineocytomas, 4 pineoblastomas, 8 pineal parenchymal tumors of intermediate differentiation were found in 21 PPTs. Immunoreactivity to Syn, NSE, NF, GFAP, NB were in 20, 20, 14, 15, 2, while Des and CK were negative in all cases. Conclusions Pineal parenchymal tumors of intermediate differentiation were characterized by a distinctly biphasic pattern, including areas of pineocytoma and pineoblastoma, or with intermediate differentiation and transitional feature. PPTs expressed neuronic differentiation. Death rate of PPTs were higher inside 1 year after the operation.

关 键 词：神经上皮肿瘤 免疫组织化学 病理学 松果体实质肿瘤 

分 类 号：R736.4[医药卫生—肿瘤]