非霍奇金淋巴瘤的IgH和TCRδ基因重排  

Rearrangement analysis of immunoglobulin heavy chain and T cell receptor δ genes in non-Hodgkin's lymphoma

作　　者：王萍[1] 王瑞年[2] 卢健[2] 陈诗书[2] 

机构地区：[1]蚌埠医学院病理学教研室,蚌埠233003 [2]上海第二医科大学生化教研室,上海200025

出　　处：《临床与实验病理学杂志》2002年第1期21-23,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的 :探讨非霍奇金淋巴瘤 (NHL)免疫球蛋白重链 (IgH)和T细胞受体δ链 (TCRδ)基因重排情况。 方法 :用半重叠式聚合酶链反应 (PCR)方法检测IgH及TCRδ基因重排。 结果 :5 7例NHL中 4 1例 (72 % )发生IgH基因重排 ,30例 (5 3% )出现TCRδ基因重排。结论 :检测克隆性基因重排可以作为诊断NHL有效基因标志 。Purpose To explore the clonal rearrangements of immunoglobulin heavy chain (IgH) and T cell receptor gene δ chain (TCR δ) in non Hodgkin's lymphoma (NHL). Methods Semi nested polymerase chain reaction (PCR) was used to study IgH and TCR δ genes rearrangements in 57 cases of NHL. Results IgH gene rearrangements were found in 41 patients,and TCR δ gene rearrangements in 30 cases. Conclusion To detect the clonality can be served as a genetic marker in the diagnosis of NHL. The lineage infidelity does occur in NHL.

关 键 词：非霍奇金氏淋巴瘤 基因重排 免疫球蛋白类 重链 受体抗原 T细胞受体δ链 TCRδ 

分 类 号：R733.1[医药卫生—肿瘤]