实体肿瘤患儿血清AFP监测  

Clinical significance of monitoring serum AFP of infants and children with solid tumors

作　　者：文建军[1] 杜长青[2] 文建国[3] 

机构地区：[1]安阳县第二人民医院外科,安阳455112 [2]郑州大学第三附属医院外科,郑州450052 [3]郑州大学第一附属医院小儿外科,郑州450052

出　　处：《郑州大学学报（医学版）》2002年第1期65-67,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:了解监测血清甲胎球蛋白(AFP)诊断小儿恶性实体肿瘤的意义。方法:采用放射免疫分析法,对106例小儿实体肿瘤、24例新生儿黄疸(包括 17例新生儿肝炎和 7例胆道闭锁)和 30名正常儿童血清 AFP进行测定。85例(80%)肿瘤患者术后随访 1个月－7 a。结果:786%肝母细胞瘤、88．9%卵黄囊瘤、31．6%骶尾部畸胎瘤、10%肾母细胞瘤和所有新生儿黄疸患儿AFP测定值同正常儿童相比明显升高(P＜0．02)。肿瘤切除后AFP多在术后2－6周恢复正常。AFP假阳性结果多发生在新生儿或小年龄组的婴幼儿。结论:测定AFP可作为诊断小儿肝母细胞瘤和卵黄囊瘤及判断肿瘤是否被完整切除和手术后有无复发的重要依据之一,但在新生儿和婴幼儿应注意假阳性结果。Aim: To investigate the clinical significance of monitoring serum AFP in infants and children with solid tumors. Methods: The serum AFP levels were determined by immunoradiometric assay in 106 children with solid tumors, 24 newborn with jaundice (17 neonatal hepatitis and 7 biliary atresia), and 30 normal control children. Eighty percent of children with tumors were followed-up for 1 month to 7 years after operation. Results: AFP increased significantly in 78.6% of hepatoblastoma, 88.9% of yolk-sac tumor, 31 .6% of benign sacrococcygeal teratoma, 10% of Wilm's tumor, and all newborn with jaundice compared with that in controls ( P < 0.02). The AFP decreased to normal within 2-6 weeks after removal of tumors. Conclusion: AFP is one of important reference for diagnosis and prognosis of pediatrie solid tumors, especially in hepatoblastoma and yolk sac tumor. However, it should be used carefully in diagnosing malignant tumor in newborns to avoid the false positive results.

关 键 词：甲胎蛋球白类 儿童 实体肿瘤 血清诊断 AFP 

分 类 号：R730.43[医药卫生—肿瘤]