膀胱移行细胞癌中细胞凋亡、P^(27)及PCNA的表达  

Apoptosis and expression of P^(27) and PCNA in bladder transitional cell carcinoma

作　　者：张东青[1] 许纯孝[1] 张怀强[1] 叶国美[1] 程继义[2] 

机构地区：[1]山东大学第二医院,山东济南250033 [2]山东省立医院

出　　处：《山东医药》2002年第7期13-14,共2页Shandong Medical Journal

摘　　要：为探讨细胞凋亡、P2 7及增殖细胞核抗原 (PCNA)表达与膀胱移行细胞癌 (简称膀胱癌 )分级、分期及预后的关系 ,采用 DNA末端标记法 (TU NEL)和免疫组化法检测 5 3例份膀胱癌组织中细胞凋亡指数 (AI)、P2 7标记指数 (P2 7L I)、PCNA标记指数 (PCNAL I)。结果显示 ,AI、P2 7L I与 PCNAL I在膀胱癌不同分级之间差异有显著性 ,PCNAL I在膀胱癌不同分期之间差异有显著性 ,而 AI与 P2 7L I在 T2 、T3间差异有显著性 ,P均 <0 .0 5。在复发的膀胱癌中 AI、PCNAL I显著高于未复发者 ,P2 7L I显著低于未复发者。表明 AI、P2 7L I、PCNALTo study the correlation between biological behavior of bladder transitional cell carcinoma and apoptosis, expression of P 27 and PCNA.AI, P 27 LI, PCNALI were detected by means of TUNEL and SABC immunohistochemical technique. AI, PCNALI elevated and P 27 LI decreased respectively with tumor grades and stages, statistical differences were observed between G 1 and G 2,G 2 and G 3 in AI, P 27 LI or PCNALI , between T 1 and T 2, T 2 and T 3 in PCNALI, and between T 2 and T 3 in AI, P 27 LI. In recurrent tumors AI and PCNALI were higher and P 27 were lower than those in non recurrent tumors. This suggest that AI, P 27 LI and PCNALI are valuable in biological activities of bladder cancer.

关 键 词：细胞凋亡 P^27 增殖细胞核抗原 膀胱肿瘤 移行细胞癌 PCNA 

分 类 号：R737.14[医药卫生—肿瘤]