细胞色素P450 2E1基因与胃癌易感性关系  

Relationship between genetic polymorphisms of cytochrome P450 2E1 and gastric cancer

作　　者：郑秋红[1] 龚福生[1] 谢云青[1] 汪相如[1] 郑天荣[1] 

机构地区：[1]福建省肿瘤医院肿瘤分子生物学研究室,福州350014

出　　处：《中华消化杂志》2002年第3期144-146,共3页Chinese Journal of Digestion

基　　金：福建省卫生厅基金资助项目 ( 0 0 70 0 1)

摘　　要：目的　探讨与致癌物亚硝胺代谢激活有关的细胞色素P45 0 (CYP) 2E1基因多型性与胃癌易感性关系。方法　采用病例对照分子流行病学研究方法 ,以聚合酶链反应 限制性片段长度多态性(PCR RFLP)技术 ,对福建省长乐市 92例胃癌病例和 92例正常对照的CYP2E1基因型进行检测。结果　在病例组和对照组中 ,RsaⅠ识别的野生型 (C1/C1)基因频率分别为 6 6 .3%和 48.9% ;DraⅠ识别的野生型 (CC)基因频率分别为 5 7.6 %和 41.3% ,差异均具有显著性 (P <0 .0 5 ) ,即具有RsaⅠ识别的C1/C1基因型或DraⅠ识别的CC基因型个体 ,患胃癌的危险性大 (OR值分别为 2 .0 6和 1.93)。联合分析表明 ,这两个位点的基因型存在某种程度的联合作用 (P <0 .0 5 )。结论　CYP2E1基因多型性可能与胃癌易感性有关。Objective To study the relationship between genetic polymorphisms of cytochrome P450 2E1(CYP2E1) and susceptibility to gastric cancer. Methods Genotype of CYP2E1 was determined by polymorphism (PCR-RFLP) analysis on DNA in 92 patients with gastric cancer and 92 controls in case-control study. Results The results showed that the frequency of the wild-type genotype (C1/C1) detected by RsaⅠ digestion was 66.3% and 48.9% in gastric cancer group and controls, respectively (P<0.05). The wild-type genotype (CC) detected by DraⅠ digestion was found in 57.6% of patients with gastric cancer, and 41.3% of controls (P<0.05). Thus, persons with wild-type genotypes detected by RsaⅠ or DraⅠ may have higher risk of developing gastric cancer (OR=2.06 and 1.93, respectively). The two locations had a combined action in developing gastric cancer. Conclusions Our results suggested that CYP2E1 gene polymorphisms may be related with gastric cancer.

关 键 词：细胞色素P4502E1 胃癌 基因多型性 易感性 

分 类 号：R735.2[医药卫生—肿瘤]