用APA微囊牛肾上腺嗜铬细胞移植治疗疼痛的研究  

STUDY OF APA BOVINE CHROMAFFIN CELL MICROCAPSULE TRANSPLANTATION FOR THE TREATMENT OF PAIN

作　　者：李涛[1] 周道标[2] 杜智[1] 孙以鲁[2] 肖琅[1] 高宝柱[1] 回建峰[1] 李学敏[1] 方淑昌[1] 李隽[1] 崔润海[1] 付立[1] 宋继昌[1] 孙绵方[2] 

机构地区：[1]天津市肝胆疾病研究所,天津300170 [2]加拿大多伦多大学

出　　处：《中国生物医学工程学报》2002年第2期97-101,共5页Chinese Journal of Biomedical Engineering

基　　金：国家"八六三"课题资助项目 ( 10 2 0 9 0 5 0 7) ;天津市自然科学基金重点课题资助项目 ( 0 0 380 3711);天津市攻关课题资助项目( 0 1310 5 911)

摘　　要：用胶原酶消化法分离牛肾上腺嗜铬细胞 ,用海藻酸钠 聚赖氨酸 海藻酸钠 (APA)法包埋牛肾上腺嗜铬细胞 ,将微囊牛肾上腺嗜铬细胞植入恶性肿瘤患者的蛛网膜下腔 ,移植后不使用免疫抑制剂。结果显示在 30例恶性肿瘤患者中 ,止痛的显效率为 6 7% (2 0例 ) ,有效率为 2 7% (8例 ) ,无效率为 6 % (2例 ) ,镇痛作用维持时间长达 15 0天。除个别患者发烧和腰痛外未发现其它明显副作用。Bovine chromaffin cells were digested and isolated with collagenase and encapsulated with alginate-polylysine-alginate, and then the bovine chromaffin cell microcapsules were transplanted into the subarachnoid space of malignant carcinoma patients. No immune suppresives were used after transplantation. Of the 30 malignant carcinoma patients who have accepted the transplantation, 67%(20) were obviously effective, 27%(8) were effective and 6%(2) had no effect. Antinociception maintained more than 150 days. There was no obvious side effect except fever and lumbago in a few patients.

关 键 词：APA胶囊 牛肾上腺嗜铬细胞 癌性疼痛 

分 类 号：R730.54[医药卫生—肿瘤] R441.1[医药卫生—临床医学]