二氢麦角碱治疗Binswanger病的前瞻性研究  

Dihydroergotoxine in treatment of Binswanger's disease:a prospective clinical trial.

作　　者：方润权[1] 肖卫民[1] 

机构地区：[1]广东省东莞市人民医院,广东东莞523000

出　　处：《四川医学》2002年第4期359-360,共2页Sichuan Medical Journal

摘　　要：目的　探讨二氢麦角碱治疗 Binswanger病的有效性和安全性。方法　将 Binswanger s病患者按随机双盲法、分成二氢麦角碱治疗组和胞二磷胆碱对照组 ,每组 30例。以简易精神状态检查 (MMSE)和日常生活能力量表 (ADL )为评价指标。结果　两组 MMSE评分在治疗后均有提高 ,二氢麦角碱治疗组提高更明显 (分别为 1.35± 1.0 8;2 .88±1.85 ) ;两组治疗后 ADL均降低 ;二氢麦角碱治疗组总有效率为 78.9% ,对照组为 5 6 .6 %。结论　二氢麦角碱能改善Objective To investigate the efficacy and safety of dihydroergotoxine in treatment of Binswangers disease patients with mild or moderate cognitive impairment.Methods A double blind,randomized,prospective drug controlled clinical trial was carried out.60 patients were individually parted in two groups:dihydroergotoxine drug one and citicolin control one.We used MMSE?Hachinski scale and ADL as main assessing items.Results 60 subjects were assessed.MMSE were raised in both groups after the treatment and more obvious in dihydroergotoxine group than in control group(1.35±1.08;2.88±1.85 respectively).ADL showed decreased scores in both groups.Total efficiency of dihydroergotoxine was 80.0% and of control was 56.6%.Conclusion dihydroergotoxine was an effective drug in treatment of Binswangers disease.

关 键 词：Binswanger's病 二氢麦角碱 前瞻性研究 治疗 

分 类 号：R749.13[医药卫生—神经病学与精神病学]