血管抑制素对胃癌生长和转移抑制作用的实验研究  

Inhibition of growth and metastasis of human gastric cancer implanted in nude mice by angiostatin

作　　者：张明敖[1] 张国锋[1] 罗芸葆[1] 王登山[2] 

机构地区：[1]上海市浦东新区人民医院普外科,201200 [2]上海市浦东新区人民医病理科,201200

出　　处：《肿瘤防治研究》2002年第2期93-95,共3页Cancer Research on Prevention and Treatment

基　　金：上海浦东新区科技专项基金资助项目 (PK2 0 0 1 1 1 )

摘　　要：目的　研究血管抑素对胃癌生长和转移的抑制作用。方法　建立人胃癌裸鼠原位种植转移模型。结果　治疗组肿瘤体积、MVD明显低于对照组 (P <0 .0 5 ) ;治疗组抑瘤率、AI明显高于对照组 (P <0 .0 5 )。胃癌转移受到明显抑制 (P <0 .0 5 ) ,且与血管抑素剂量呈正相关。结论　血管抑素通过抑制血管生成 ,诱导胃癌细胞凋亡 。Objective To study the effects of angiostatin on the growth and metastasis of gastric cancer in vivo. Methods Metastatic model simulating human gastric cancer was established by orthotopic implantation of histologically intact human tumor tissue into gastric wall of nude mice. Results The MVD were decreased significantly in the treated mice ( P <0.05). The AI were increased significantly in the treated mice ( P <0.05). Tumor metastasis to the liver and peritoneaum was also significantly inhibited in a dose-dependent manner ( P <0.05). Conclusion Angiostatin can induce apoptosis in gastric cancer by inhibiting tumor angiogenesis and has strong inhibitory effect both on tumor growth and metastasis of human gastric cancer implanted in nude nude.

关 键 词：胃肿瘤 肿瘤转移 细胞凋亡 血管抑制素 实验研究 

分 类 号：R735.2[医药卫生—肿瘤] R73－36[医药卫生—临床医学]