室内环境污染、神经精神等因素与肺癌关系的研究  

A case-control study on the relationship among indoor air pollution,depression and oncogenesis of lung cancer

作　　者：孙喜文[1] 戴旭东[1] 石于波[1] 林英姬[1] 

机构地区：[1]哈尔滨医科大学肿瘤防治研究所,150040

出　　处：《中国肺癌杂志》2002年第2期101-103,共3页Chinese Journal of Lung Cancer

摘　　要：目的　探讨室内环境污染、神经精神等因素与肺癌发生的关系。方法　利用 1∶3配对的病例对照研究调查被访者既往暴露史 ,用条件Logistic回归分析诸因素的比值比及其 95 %可信区间。结果　经调整混杂因素后本研究结果提示 ,用煤量≥ 46kg m2 可使肺癌危险性增加 12 2 % ,煤炉取暖增加肺癌危险性 113% ;婚姻生活不和谐或破裂、自我调节能力差、不易适应环境以及人际关系较差均使肺癌危险性增加 5倍以上。经常暴露于室内油烟 ,且精神长期处于压抑状态或具有较大的精神创伤 ,可使肺癌危险性明显增加。结论　室内空气污染、神经精神因素等是肺癌发生的重要因素。Objective To evaluate the relationship among indoor air pollution, depression and oncogenesis of lung cancer. Methods An 1∶3 matched case-control study was carried out. Conditional logistic regression was applied to process the data. Results After some confounding factors were adjusted, the ORs increased 122% and 113% for the amount of coal using ≥46?kg/m 2 and heating by coal stove respectively. The ORs elevated more than five-folds for disharmony and rupture of marriage, difference of accommodation and acclimation by oneself and human relationship respectively. The risk of lung caner obviously increased for frequent exposure to indoor cooking smoke combinated with depressed mood or mental scar respectively. Conclusion The indoor air pollution, depression and mental scar are important factors of oncogenesis of lung cancer.

关 键 词：肺肿瘤 室内空气污染 精神压抑 危险因素 

分 类 号：R734.2[医药卫生—肿瘤]