无水酒精局部注射治疗复发性肝癌对癌细胞血行播散的影响  

Peripheral blood determination of AFP mRNA in patients with recurrent hepatocellular carcinoma (HCC) undergoing percutaneous ethanol injection (PEI)

作　　者：刘扬[1] 宗明[1] 张柏和[1] 钱光相[1] 杨甲梅[1] 杨广顺[1] 陈汉[1] 吴孟超[1] 

机构地区：[1]第二军医大学东方肝胆外科医院,上海200438

出　　处：《中华普通外科杂志》2002年第4期207-208,共2页Chinese Journal of General Surgery

摘　　要：目的　探讨无水酒精局部注射 (PEI)术治疗复发性肝癌对癌细胞血行播散的影响。方法　应用巢式RT PCR检测复发性肝癌患者PEI术前后周围静脉血液中肝癌细胞的变化。结果　2 9例复发性肝癌患者PEI术前有 14例 (4 8% )周围血液中肝癌细胞阳性者 ;PEI治疗 4次 (1个疗程 )后阳性者减至 2例 (7% )。Objective To study the effect of PEI on disseminating HCC cells in the peripheral blood in patients with recurrent HCC. MethodsWe examined blood samples from 29 recurrent HCC patients by nested RT-PCR for the determination of AFP?mRNA before and 1, 2, 3 and 4 weeks after PEI.ResultsBefore PEI 14 (48%) patients out of the 29 cases with recurrent HCC were positive with AFP?mRNA. Four weeks after a course of PEI only 2 cases (7%) remained AFP?mRNA positive.ConclutionsPEI effectively eradicating disseminating HCC cells in the peripheral blood shows a favourable potential for the treatment of recurrent HCC.

关 键 词：聚合酶链反应 局部注射 无水酒精 复发性肝癌 血行播散 

分 类 号：R735.7[医药卫生—肿瘤]