事件相关电位N270在揭示帕金森病患者轻度认知损害中的应用  

The application of event-related potential N270 in detecting mild cognitive impairment in Parkinson disease

作　　者：王玉平[1] 王惠军[1] 王德泉[1] 崔莉莉[1] 田书娟[1] 张媛媛[1] 

机构地区：[1]首都医科大学北京宣武医院神经内科,100053

出　　处：《中华神经科杂志》2002年第1期9-12,共4页Chinese Journal of Neurology

基　　金：北京市自然科学基金资助项目 ( 70 0 2 0 2 1) ;北京市神经退行性疾病重点课题的部分资助项目

摘　　要：目的　寻找揭示帕金森病患者轻度认知损害的敏感指标。方法　 30例非痴呆帕金森病患者和 34名年龄匹配的正常对照参与本研究。成对的刺激 (S1和S2 )依次呈现 ,共有两种类型 :(1)S1和S2颜色匹配 ;(2 )S1和S2颜色冲突。受试者比较S1和S2颜色是否相同 ,同时在头皮记录事件相关电位。结果　无论患者组还是对照组 :颜色匹配时 ,S2诱发出P10 0、N15 0、P180、N2 0 0和P30 0 ;冲突时 ,在N2 0 0后P30 0前又出现了另一个负波———N2 70。两组间N15 0的潜伏期以及振幅均无显著性差异。患者组N2 70的峰潜伏期长于对照组 [P3,患者组 (317± 37)ms,对照组 (2 98± 31)ms];振幅低于对照组 [P3,患者组 (- 3 1± 2 5 ) μV ,对照组 (- 4 6± 2 9) μV]。患者组P30 0的峰潜伏期与对照组无显著性差异 ,仅峰振幅低于对照组。结论　非痴呆帕金森病患者存在认知功能损害 ,N2 70在检测这一认知损害时比P30 0更敏感。Objective To find a sensitive index which can reveal the mild cognitive impairment in non-demented patients with Parkinson’s disease (PD).Methods Thirty PD patients without clinical dementia and 34 age-matched normal controls performed a matching-to-sample task while event-related potential (ERP) was recorded from their scalp. There were two kinds of stimulus pairs in this study: condition 1, the second stimulus (S2) in a pair was identical to the first one (S1) (match condition); condition 2, S2 conflicted with S1 in their color attribute (conflict condition). Subjects were required to press a button in the match condition and another button in the conflict condition.Results In the match condition, P100, N150, P180, N200, and P300 were elicited by S2. In the conflict condition, potentials following N200 went continuously to negativity and formed another component,N270,before P300. The N270 component was evoked by S2 of conflict condition in both controls and patients. The patient group showed a delayed and smaller N270 than the control group[peak latency: P3,patients:(317±37) ms,controls:(298±31) ms;P4, patients: (313±35) ms,controls: (293±34) ms;amplitude: P3,patients: (-3.06±2.51) μV,controls: (-4.55±2.86) μV]. The peak amplitude of P300 was decreased in the patient group [P4,patients: (6.94±3.95) μV,controls: (9.58±3.80) μV], but the peak latency of P300 did not differ significantly between the two subject groups. There was no difference between the two groups in peak latency and amplitude of N150.Conclusion PD patients have cognitive impairment even in the absence of a clinical dementia. N270 is subtler than P300 in revealing the mild cognitive impairment.

关 键 词：帕金森病 认知障碍 诱发电位 

分 类 号：R742.5[医药卫生—神经病学与精神病学]