微粒子酶免疫法检测鼻咽癌鳞癌相关抗原的临床评价  

CLINICAL EVALUATION OF MICROPARTICLE ENZYME IMMUNOASSAY FOR SQUAMOUS CELL CARCINOMA ANTIGEN(SccAg) IN NASOPHARGNGEAL CARCINOMA.

作　　者：郑辉[1] 李健茹[1] 

机构地区：[1]广东省江门市中心医院检验科,529071

出　　处：《现代预防医学》2002年第2期188-189,共2页Modern Preventive Medicine

摘　　要：目的 :评价检测血清 Scc Ag水平在鼻咽癌诊断中的意义。方法 :用 MEIA法测定鼻咽癌患者血清 Scc Ag(鳞癌相关抗原 )水平 ,以鼻咽部良性病变患者为对照。分析灵敏度、特异性、预示值等有关的诊断评价指标。结果 :鼻咽癌鳞癌及非鳞癌患者血清 Scc Ag水平无明显差异 ,两者与对照相比 ,差异显著。Scc Ag诊断鼻咽癌的灵敏度为 6 .41% ,特异性10 0 % ,阳性预测值 10 0 % ,阴性预测值 6 0 .75 %。结论 :血清 Scc Ag不是筛选或诊断鼻咽癌的较好指标 ,Scc Ag测定不能区别鳞癌鼻咽癌与非鳞癌鼻咽癌 。Objective:To evaluate the significance of microparticle enzyme immunoassay(MEIA) for determinating of squamous cell asscoiated antigen(SccAg) in patients with nasopharyngeal carcinoma(NPC).Methods:Serum SccAg level is in NPC patients was determined by MEIA,and their diagnostic sensitivity,specificity and predictive values for NPC were also analyzed.Patients with benign nasopharyngeal diseases were used as control.Rusults:Levels of serum SccAg between Nasopharyngeal squamous cell carcinoma and nasophatyngeal non-squamous cell carcinoma were not significant,and comparable to those in controls.The sensitivity,specificity,positive predicative value and negative predicative value of serum SccAg for NPC were 6.41%,100%,100% and 60.75%,respectively.Conclusions:Serum SccAg is not a good index for NPC.Serum SccAg detection can not be used to defficiate nasopharyngeal squamous cell carcinoma and nasopharyngeal non-squamous cell carcinoma,but it can be used as an assistant index to differentiate nasopharyngeal benign and nign diseases.

关 键 词：鳞癌抗原 鼻咽癌 微粒子酶免疫法 检测 

分 类 号：R739.63[医药卫生—肿瘤]