平阳霉素等联合治疗颌面部海绵状血管瘤58例  

Effect of Pinyangmycin in Combination of Other Drugs in the Treatment of Cavernous Hemangioma in Maxillofacial Region

作　　者：胡强[1] 张志红[1] 王秀荣[1] 

机构地区：[1]湖北省襄樊市中心医院口腔科,441021

出　　处：《医药导报》2002年第4期214-215,共2页Herald of Medicine

摘　　要：目的 :探讨平阳霉素、地塞米松和鱼肝油酸钠联合治疗颌面部海绵状血管瘤的疗效。方法 :颌面部海绵状血管瘤患者 5 8例 ,用平阳霉素 8mg溶解在地塞米松溶液 1mL内 ,加 1%普鲁卡因 4mL ,然后将上述液体注射于血管瘤瘤体内 ,根据瘤体的大小、患者年龄 ,再注射 0 .5～ 2 .0mL鱼肝油酸钠。一般平阳霉素每次不超过 8mg ,1周注射 1次 ,3～ 5次为 1个疗程 ,平阳霉素总量 <40mg。结果 :5 8例患者经治疗后 2a随访 ,治愈率 74.14 % ,基本治愈率 2 0 .69% ,好转 5 .17% ,总有效率 10 0 .0 0 %。结论 :平阳霉素、地塞米松及鱼肝油酸钠联合注射治疗颌面部海绵状血管瘤安全有效。Objective:The purpose of this study is to assess the effect of local injection of pinyangmycin mixed with dexamethason and sodium morrhuate for treating cavemous hemangioma in the maxillofacial region. Methods:58 patients with cavemous hemangioma in the maxillofacial region were recruited for this study. 8 mL of pinyangmycin was dissolved in 1 ml (5 mg) of dexamethason, and then mixed with 4ml of 1% procaine. 1～5 mL (pinyangmycin 1.6～8.0 mg) of the aforementioned mixed solution was injected into the hemangioma, followed by an injection of 0.5～2.0 mL of sodium morrhuate, according to the local appearance, size of the tumor and patient's age. Generally, the amount of each injection should not be over 8 mg of pinyangmcin. If the tumor did not subside after an injection, another injection might be repeated every 5～7 days, and this process might be repeated 3～5 times. However, the total dose of pinyangmcin should not be over 40 mg. Results: The 58 patients were followed up for two years. 43 out of the 58 (74.14%) patients recovered completely, 12 (20.69%) recovered nearly completely, and 3 (5.17%) improved to some extend. The total effectiveness rate was 100%. Conclusion:Using pinyangmycin in combination with dexamethason and sodium morrhuate for local injection is an effective and safe method for treating hemangioma in the maxillofical region.

关 键 词：鱼肝油酸钠 地塞米松 药物疗法 治疗 平阳霉素 联合治疗 颌面部海绵状血管瘤 

分 类 号：R739.81[医药卫生—肿瘤] R979.1[医药卫生—临床医学]