抑郁症患者吗氯贝胺治疗前后血清T3、T4、TSH的变化  

Changes of Serum Thyroid Hormones before and after Moclobemide Treated with Depression Patients

作　　者：胡峻梅[1] 胡世辉[2] 袁化学[2] 李奕[2] 王洪明[2] 

机构地区：[1]四川大学华西医院精神科,四川成都610041 [2]四川省成都市第四人民医院,四川成都610036

出　　处：《华西医学》2002年第1期41-42,共2页West China Medical Journal

摘　　要：目的 :探讨吗氯贝胺治疗抑郁症时对血清T3、T4、TSH含量的影响。方法 :采用酶免疫定量检测法分别测定了 16例健康对照组及 16例抑郁症病人治疗前、后的甲状腺素水平 ,同时采用HAMD、HAMA对病人治疗前后的症状进行评定。结果 :抑郁症组T3、T4、TSH与对照组无显著性差异 ;16例病人经吗氯贝胺治疗 6周后T4及HADS、HAMS分较治疗前显著降低、TSH显著升高。结论 :吗氯贝胺在抗抑郁的同时对血清T4、TSH水平有影响。Objective:To imvestigated the ch anges of serum T3,T4,TSH and depression symptom in depressed patients treated with moclobemide.Methods:Serum T3,T4,TSH were measured in 16 depression inpatien ts and 16 normal control,at same time HAMD?HAMA and T3,T4,TSH were monitored in p a tients before and after treatment.Results:No significantl differenced was found between depression and normal subjects in serum T3,T4 and TSH.The T4?HAMD and H AMA scale of 16 patients were significantly decreased but TSH significantly incr ease d after treatment of moclobemude.Conclusion:Moclobemide may imflutrce thyroid ho rmones when used as antidepressed medication.

关 键 词：抑郁症 甲状腺激素 吗氯贝胺 T3 T4 TSH 

分 类 号：R749.4[医药卫生—神经病学与精神病学]