血清唾液酸测定对口腔颌面部肿瘤诊断及疗效观察的意义  

Clinical significance of determination of serum sialic acid in patients with oral and maxillofacial tumors

作　　者：张福军[1] 季平[1] 陈睿[1] 唐鹏[1] 

机构地区：[1]重庆医科大学临床学院口腔科,重庆400016

出　　处：《重庆医科大学学报》2002年第1期76-78,共3页Journal of Chongqing Medical University

摘　　要：目的：　探讨血清唾液酸（ＳＡ）检测对口腔颌面部肿瘤诊断及疗效观察的应用价值。方法：　对１５１例血清标本进行了唾液酸（ＳＡ）的检测。结果：恶性肿瘤组血清ＳＡ含量明显高于正常对照组和良性肿瘤组（ｑ　＝１８．７５～２１．０４，　Ｐ　＜０．０１）；　恶性肿瘤组经手术及化疗等治疗显效者，血清ＳＡ水平显著下降（ｔ　＝９．８０～３５．３５，　Ｐ　＜０．０１），但仍高于正常组（ｔ　＝７．２０，　Ｐ　＜０．０１）；ＳＡ水平持续保持在高水平甚至上升则预后较差。结论：　血清ＳＡ测定对口腔颌面部肿瘤诊断及疗效观察有一定的参考价值。Objective: To study the use of determination of serum sialic acid in diagnoses and curative effect observation of oral and maxillofacial tumors. Methods: The contents of SA of 151 samples including 60 normal persons, 53 benign and 38 malignant oral-facial tumors were determined. Results:The contents of serum SA of the patients with malignant tumors were significantly higher than that of normal persons and the patients with benign tumors (q =18.75～21.04,P<0.01). The contents of serum SA of the patients with malignant tumors were significantly decreased when the therapy (including operation and chemotherapy) was effective(t =9.80～35.35, P<0.01), but were still higher than that of normal persons（t =7.20, P<0.01）. On the contrary, the contents of serum SA remained high or even higher when the malignant tumors recurred or metastasized. Conclusion: Determination of serum SA was valuable in diagnoses and curative effect observation of oral and maxillofacial tumors.

关 键 词：血清唾液酸 诊断 疗效观察 口腔颌面部肿瘤 

分 类 号：R739.81[医药卫生—肿瘤] R730.43[医药卫生—临床医学]