共刺激信号在抗肝脏肿瘤免疫中作用的研究  

Study on the effect of costimulation in anti-liver tumor immune

作　　者：李依娜[1] 黄树林[2] 罗利琼[2] 

机构地区：[1]广东药学院微生物学与免疫学教研室,广东广州510224 [2]广东药学院分子生物学研究室

出　　处：《广东药学院学报》2002年第1期29-30,共2页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的 :研究共刺激信号在抗肝脏肿瘤免疫中作用。方法 :分析经anti CD3McAb和anti CD2 8McAb协同共刺激 ,并与肝脏肿瘤细胞 (HepG2 -2 2 15细胞株 )共同孵育的人外周血淋巴细胞 (PBLs)。结果 :发现其TCRVβ基因表达呈限制性 ,初步筛选出识别肝脏肿瘤抗原的TCRVβ基因亚家族。结论 :有针对性地在体外大量扩增表达Vβ3、Vβ14的T细胞并回输给该肝脏肿瘤患者 。The expression of TCRVβ genes in peripheral blood lymphocytes (PBLs) costimulated by anti CD3McAb and anti CD28McAb and incubated with hepatocellular carcinoma (HCC) cell line (HepG 2-2215) were analyzed. The result indicated a restricted TCRVβ usage in HCC.The TCRVβ gene sub families recognizing liver tumor antigens were screened.

关 键 词：共刺激 TCRVΒ基因 免疫治疗 肝肿瘤 

分 类 号：R735.7[医药卫生—肿瘤]