生长抑素类似物及其标记核素  

Recent development of radio-labeled somatostatin analogues as receptor image agent

作　　者：向艳[1] 夏劲松[1] 

机构地区：[1]华中科技大学同济医学院,武汉430022

出　　处：《国外医学（放射医学核医学分册）》2002年第1期21-24,共4页Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)

摘　　要：利用标记小肽进行功能显像有望开创核素显像与肿瘤生物学研究的新纪元。为了提高肿瘤生长抑素受体显像的特异性和敏感性 ,从受体亚型水平开发受体显像剂 ,以及研究适合临床应用的简捷标记方法是今后的重要课题。The development of radiolabeled peptide_based radiopharmaceuticals for imaging a variety of tumors has seen a new era in nuclear medicine. Recently, a number of radio_labeled somatostatin analogues have proven to be useful diagnostic imaging agents.The challenge is to synthesize a wide range of biologically active somatostatin analogue peptides without affecting their receptor binding properties,and label bioactive peptides with radionuclides with high specific activity without impairing the biological properties of the peptides.This review presents recent developments in radio_labeled somatostatin analogues and their pharmacokinetic properties,their potential as diagnostic imaging agents are also addressed.

关 键 词：受体显像 生长抑素类似物 核素 多肽 肿瘤 

分 类 号：R817[医药卫生—影像医学与核医学]