丙戊酸钠在脑肿瘤术后的临床应用  

Postoperative clinical application of sodium valproate on brain tumors

作　　者：邱炳辉[1] 欧阳辉[1] 漆松涛[1] 冯文峰[1] 方陆雄[1] 彭玉平[1] 

机构地区：[1]中国人民解放军第一军医大学南方医院神经外科,广东广州510515

出　　处：《中国新药与临床杂志》2002年第4期205-207,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :评价丙戊酸钠在脑肿瘤术后的临床疗效。方法 :对 15 0例脑肿瘤病人随机分成丙戊酸钠治疗组 (丙戊酸钠组 ,n =77)和对照组 (n =73) ,观察手术后病人的生命体征、癫痫发作、颅内压和脑水肿变化情况。结果 :脑肿瘤术后丙戊酸钠组病人癫痫发生率 (5 % )、颅内压显著升高 (8% )和重度脑水肿 (4 % )与对照组 (分别为 19% ,2 2 % ,16% )比较差异有显著和非常显著意义 (P <0 .0 5或P <0 .0 1)。 2组治疗后 3wk病人恢复情况比较差异有显著意义 (P <0 .0 5 ) ,致残率 (5 % )明显低于对照组 (15 % ) (P <0 .0 5 )。结论 :脑肿瘤术后早期应用丙戊酸钠可以降低癫痫发生率 ,减轻脑水肿 ,降低颅内压升高幅度 ,减少致残率 。AIM: To evaluate the effects of sodium valproate in treating brain tumors postoperation. METHODS: One hundred and fifty patients with brain tumors (77 patients were treated with sodium valproate and 73 patients were as control) were analyzed on vital signs, epileptic seizure, intracranial pressure and brain edema. RESULTS: The vital signs in the postoperation 7 d were smooth in both groups. The rate of epileptic seizure (5 %), the advance of intracranial pressure (8 %) and the severity of brain edema (4 %) in sodium valproate group was less remarkable than those in control group ( P <0.01 or P <0.05). The prognosis of patients in sodium valproate group was better than control group ( P <0.05) after treatment for 3 wk, and the rate of disability (5 %) was less than that (15 %) in control group ( P <0.05). CONCLUSION: The early use of sodium valproate in postoperation patients with brain tumors can reduce the rate of epileptic seizure and disability, relieve the brain edema and intracranial pressure, improve the recovery of neurological function.

关 键 词：丙戊酸钠 脑肿瘤 癫痫 药物治疗 临床应用 外科手术 

分 类 号：R739.41[医药卫生—肿瘤] R730.56[医药卫生—临床医学]