自由基与白血病关系的研究进展  

The Update Achievements on the Relation between Free Radical and Leukemia

作　　者：许芳[1] 

机构地区：[1]四川大学华西医院血液科,成都610041

出　　处：《中国实验血液学杂志》2002年第2期163-167,共5页Journal of Experimental Hematology

摘　　要：自由基是一类带电荷的原子、分子或离子 ,具有很强的生物活性 ,在肿瘤和其它许多疾病的发生过程中起重要作用。自由基在人体内通过一系列级联反应产生或消亡 ,它可以激活癌基因 ,在细胞内参与肿瘤细胞凋亡、生存、增殖相关的信号传导 ,修饰关键酶或蛋白并改变其功能 ,从而导致肿瘤的发生 ,同时对组织、器官造成损伤 ,产生多种病理变化。Free radicals are a group of charged atoms, molecules or ions with strong biological activity, which play an important role in pathogenesis of cancers and many other diseases. Free radicals are produced and consumed by a serial of chain reactions. Free radicals can activate pro oncogenes, impact the signal transduction about the apoptosis, survival and proliferation of tumor cells, modify the key enzymes or proteins functions, and might cause carcinogenesis. Meanwhile, free radicals damage the tissues and organs and bring about a variety of pathological changes. On the other hand, free radicals are involved in the effects of some anti leukemic drugs as intermediates or functional substances.

关 键 词：自由基 白血病 抗白血病药物 发病机制 药理作用 

分 类 号：R733.7[医药卫生—肿瘤]