荧光-电信号转换系统对内镜活检的引导作用  

Effect of laser induced fluorescence-electrial signal on guiding biopsy under endoscopy

作　　者：盛剑秋[1] 李世荣[1] 徐智[2] 郁道银[2] 高革[1] 樊翠珍[3] 

机构地区：[1]北京军区总医院消化内科,100700 [2]天津大学精密仪器系 [3]郑州大学医院肿瘤科

出　　处：《中华消化杂志》2002年第2期100-102,共3页Chinese Journal of Digestion

摘　　要：目的　内镜下激光诱发荧光活检引导技术已日趋成熟 ,但仪器的昂贵限制了这种技术的开发与使用。本研究拟采用光 电信号转换系统代替弱光检测仪 (OMA) ,进行临床验证。方法　根据4 2例已知胃肠道癌组织的荧光谱特征 ,建立两个荧光判别公式。依据公式要求 ,研制新的荧光活检引导仪。以该仪器和OMA仪同步检测 15例体外胃肠道癌和 4 0例内镜下疑为癌的病例 ,并计算其判断敏感性和特异性。结果　 1.根据已知病例 ,建立了癌判别公式 :①组织荧光总能量 =35 9～ 6 5 9nm的荧光积分 ;②组织荧光能量积分比 =W3 95～ 460nm/W460～ 659nm。以公式②判别 15例体外胃肠道癌的敏感性为93.3% ,特异性 10 0 .0 %。以公式②判别内镜下胃肠道癌的敏感性为 90 .0 % ,特异性为 92 .5 %。结论　该仪器可协助内镜医师实时、无创地判断镜下病变性质。新的荧光活检引导仪在判别胃肠道良、恶性病变的效能上与国际上广泛应用的OMA相等 。Objective Laser induced fluorescence spectroscopy have been used in early diagnosis of GI cancer, but the device is expensive and inconvenient. The purpose of this study was to test the effectiveness and feasibility of a new device designed by the authors. Methods Two formulas were set up based on the analysis of OMA data and a new system was established. Fifteen samples of normal tissue and 40 cases of endoscopic diagnosed cancer were tested. Results (1) First formula: general energy of fluorescence was W 359～659 nm . (2) The second: the ratio of energy integral was W 359～460 nm /W 460～659 nm . (3) The sensitivity and specificity were 93.3% and 100.0% for 15 samples of gastro intestinal cancer in vitro and were 90.0% and 92.5% respectively for gastrointestinal cancer endoscopically. Conclusions (1) The deviec may help doctors to determine the characteristics of lesion in endoscopy and the efficacy of the instrument was the same as OMA system. (2) The cost was about one tenth of that for OMA system.

关 键 词：荧光-电信号转换系统 内镜活检 引导作用 胃肠疾病 诊断 

分 类 号：R573[医药卫生—消化系统]