重组生长激素对小鼠血液细胞学指标变化的初步观察  

Observation of the effect of recombinant human growth hormone on the hemato-cytology of mice

作　　者：佟力[1] 杨凌[2] 肖敏[2] 

机构地区：[1]昆明医学院第一附属医院检验科,云南昆明650032 [2]昆明医学院第一附属医院血液内科,云南昆明650032

出　　处：《云南医药》2002年第2期87-88,共2页Medicine and Pharmacy of Yunnan

摘　　要：目的　探讨重组生长激素 (rhGH)对小鼠血液细胞学指标的变化。方法　应用CELL -DYN 170 0及骨髓涂片来监测rhGH对 30只小鼠的造血细胞增殖能力的作用。结果　阳性对照组周围血细胞计数明显低于生理盐水对照组 (P <0 0 1) ,实验组周围血细胞计数与生理盐水组比较无明显差异 (P >0 0 5 )。实验组骨髓细胞形态学检查与生理盐水对照组比较 ,除粒细胞系统增生稍减低外 ,其它各系统均无明显变化。阳性对照组骨髓中有核细胞增生减低及明显减低 ,粒细胞系统形态异常。Objective To investigate the effect of recombinant human growth hormone on hematolo-cytology of the mice.Methods With CELL-DYN 1700 and bone marrow smear,the proliferation of hemopioetic progenitors was observed on thirty mice received rhGH therapy.Results Peripheric blood cell count in positive control group had significant changes ,while peripheric blood cell count in tested group and in negative control group were nonsignificant .Myelogram in tested group and in negative control group were nonsignificant,except for a hypoplastic granulocytopoiesis in tested group.Marrow in positive control group was hypoplastic or marked hypoplastic, and morphology of granulocyte series was abnormal.Conclusion rhGH have a protective effect on hemopoiesis of mouse receiving chemotherapy.

关 键 词：重组生长激素 小鼠 血液细胞学 指标变化 初步观察 骨髓 外周血 细胞增殖 RHGH 白血病 

分 类 号：R733.7[医药卫生—肿瘤] Q575.11[医药卫生—临床医学]