模拟高原缺氧条件下大鼠记忆行为变化及其突触机制  

Changes of memory behavior and its synaptic mechanism in rats exposed to simulated high altitude

作　　者：隋建峰[1,2] 熊雄[1,2] 熊鹰[1,2] 

机构地区：[1]重庆市沙坪坝区高滩岩新街30号第三军医大学,重庆400038 [2]重庆市沙坪坝区高滩岩新街30号第三军医大学附属一院,重庆400038

出　　处：《中国行为医学科学》2002年第2期125-126,共2页Chinese Journal of Behavioral Medical Science

摘　　要：目的　探讨高原低氧对大鼠学习记忆脑高级功能的影响及其神经机制。方法　两组大鼠分别在模拟海拔 5 5 0 0 ,6 0 0 0米高度的低压舱内每天生活 2小时 ,连续一周 ,然后观察其爬杆反应行为学指标以及海马神经元突触结构参数变化。结果　与对照组相比 ,海拔 6 0 0 0米低压低氧组大鼠出现爬杆条件回避反应的习得和保持率下降 ,突触后致密物质 (PSD)厚度下降 ,长度缩短 ,突触间隙相应增宽 ,突触穿孔现象减少。 5 5 0 0米组无上述作用。结论　海马神经元突触结构异常是低压低氧条件下大鼠学习记忆脑高级功能障碍的形态学基础。Objective To discuss the effects and neuro mechanism of hypobaric hypoxia on higher brain functions of learning and memory in rats.Method Changes of learning,memory behaviors in pole jumping tests and synaptic structural parameters in hippocampal neurons in rats were tested after exposure to simulated high altitude of 5500m and 6000 m,for 2 hours perday, 6 days successively.Results In the hypoxia group of 6000 m above sea level, the acquisition and retainable rate of pole jumping active avoidance response and the thickness of postsynaptic densities (PSD) decreased obviously,the longevity of PSD shortened markedly, the width of synaptic cleft increased and the perforated synapses reduced significantly compared with the control group.In hypoxia group of 5500m, no above changes were found.Conclusions The structural abnormalities of the hippocampal neuronal synapses is the morphological basis of abnormalities of higher brain functions of learning and memory induced by hypobaric hypoxia.

关 键 词：大鼠 记忆行为 低氧 低气压 突触 海马 

分 类 号：R363[医药卫生—病理学]