肺癌组织中CD44v6和nm23H1基因的表达及临床意义  

CLINICAL SIGNIFICANCE OF THE EXPRESSION OF CD44v6 AND NM23H1 GENES IN LUNG CANCER TISSUE

作　　者：谷化平[1] 刘艳茹[2] 倪灿荣[3] 

机构地区：[1]解放军251医院病理科，河北张家口 075000 [2]内蒙古自治区医院十四病房 [3]第二军医大学长海医院病理科

出　　处：《中国组织化学与细胞化学杂志》2002年第1期98-101,共4页Chinese Journal of Histochemistry and Cytochemistry

摘　　要：目的　为了探讨肺癌组织中 CD44 v6 m RNA和 nm 2 3H1m RNA表达与临床意义及其相关性。方法　应用原位杂交催化信号放大方法 ,检测 6 5例肺癌组织中 CD44 v6 m RNA和 nm2 3H 1m RNA表达 ,结合临床病理指标及随访病例进行研究分析。结果　在肺癌中 CD44 v6 m RNA和 nm 2 3H1m RNA表达阳性率分别为 6 6 .2 %和 49.2 %。 CD44 v6 m RNA高表达和 nm 2 3H 1m RNA低表达均与肺癌 Pathological tum or node meyastasis (PTNM)分期、病理分级和淋巴结转移呈正相关。结论　肺癌 CD44 v6 m RNA表达与 nm 2 3H1m RNA表达呈负相关。肺癌中 CD44 v6 m RNA表达与 nm 2 3H1m RNA表达密切相关性 ,两者均可作为预测肺癌转移和评估预后的重要指标。? Objective To study the clinical significance of CD44v6 mRNA and nm23H1 mRNA expressions and their correlation. Methods Catalyzed signal amplification method of in situ hybridization was used to detect the expression of CD44v6 mRNA and nm23H1 mRNA in 65 cases of lung cancer. The clinical pathologic parameter and follow up material were also investigated. Results The positive expression rates of CD44v6 mRNA and nm23H1 mRNA were 66 2% and 49 2% respectively in lung cancer.The overexpression of CD44v6 mRNA and the low expression of nm23H1 mRNA were correlated with the pathological tumor node metastasis stage, pathology grade and lymph node metastasis.CD44v6 mRNA expression was negatively correlated with nm23H1 mRNA expression.Conclusion Considering their significant correlation in lung cancer, combining the detection of the expression of these two mRNA may sevre as an important index to evaluate the metastasis and prognosis of lung cancer.\;〔

关 键 词：肺癌组织 CD44V6基因 NM23H1基因 表达 临床意义 原位分子杂交 

分 类 号：R734.2[医药卫生—肿瘤]