恶劣心境障碍患者综合治疗前后听觉事件诱发电位的变化  

A clinical study of the effect of composite therapy on patients with dysthymic disorder

作　　者：戴光明[1] 肖道宏[1] 张雪松[1] 代芬[1] 

机构地区：[1]解放军第三军医大学新桥医院,重庆400037

出　　处：《中国临床康复》2002年第7期974-975,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的恶劣心境障碍患者听觉事件诱发电位(P300)的变化及综合治疗对P300的影响。方法恶劣心境障碍患者150例,予综合治疗8周前后分别进行抑郁量表和听觉P300测查。结果治疗前患者自评和他评抑郁总分均增高,P300潜伏期延长、波幅低;治疗8周末,临床症状改善,两种抑郁量表总分显著降低,P300潜伏期明显缩短、波幅亦增高。结论恶劣心境障碍患者存在认知功能P300改变,并能通过综合治疗恢复。Objective To explore the effect of composite therapy on patients with dysthymic disorder,we observed the changes of auditory P300 and the scores of SAS and HAMD in the patients treating with compostite therapy.Method We evaluated the scores of SAS and HAMD and measured the latencies and amplitude of auditory P300 in patients with dysthymic disorder before and after treatment with composite therapy.Result Before treatment,the scores of SAS and HAMD were both significantly higher than normal ones.The latencies of auditory P300 were prolonged and the amplitudes reduced obviously.After treatment,the scores of SAS and HAMD decreased and latencies and amplitudes of auditory P300 improved significantly.Conclusion The patients with dysthymic disorder have congnitive impairment which is suggested by the abnormality of auditory P300.The composite therapy can improve the cognitive impairment and reduce the sores of SAS and HAMD in patients with dysthymic disorder.

关 键 词：恶劣心境障碍 听觉事件诱发电位 综合治疗 抑郁障碍 

分 类 号：R749.4[医药卫生—神经病学与精神病学]