α-干扰素对慢性乙型肝炎患者肝纤维化指标和组织学变化的影响  

Effect of interferon alpha on serological fibrosis markers and histology of patients with chronic hepatitis B

作　　者：张惠芸[1] 吕卉[1] 袁孟彪[2] 

机构地区：[1]济南市传染病医院,山东济南250021 [2]山东大学齐鲁医院

出　　处：《山东医药》2002年第5期16-17,共2页Shandong Medical Journal

基　　金：济南市卫生局资助课题 ( NO:1999第 2 3号)

摘　　要：为探讨α-干扰素 ( IFN-α)的抗肝纤维化作用 ,应用 IFN- a1b治疗中度、重度慢性乙型肝炎 ( CHB)及早期肝硬化患者 116例 ,并于治疗前后用酶免法检测其血清透明质酸 ( HA)、层粘连蛋白 ( L N)、 型胶原 ( C ) ,进行肝组织活检。结果显示 ,治疗前血清 HA、L N、C 水平随 CHB病程进展逐渐升高 ,与其肝纤维化程度一致 ,以S4 期水平最高 ;治疗后患者血清 HA、L N、C 均有不同程度的改善 ( CHB中度 P均 <0 .0 1,重度 P均 <0 .0 5 ;肝硬化三项指标分别为 P<0 .0 5、>0 .0 5、>0 .0 5 ) ,且肝纤维化程度改善 ,免疫组化 L N、C 表达受到明显抑制。认为 IFN-α对To study the efficacy of interferon alpha(IFN α)against liver fibrosis,IFN α 1b was given to 116 patients with moderate and severe chronic hepatitis B(CHB)including early cirrhosis In the beginning and at the end of therapy,serum hyaluronic acid(HA),laminin(LN),type Ⅳ collagen(CⅣ)were detected by EIA and liver biopsy were performed Besides,LN,CⅣ were assayed by immunohistochemical methods The results showed that serum HA,LN and CⅣ increased with the progression of CHB,and were in accordance with fibrotic stag ing The serum markers reached the highest at S 4 Serum HA,LN and CⅣ decreased in variable degrees in moderate cases with CHB,P<0 01,in severe cases P<0 05,in cirrhosis,P<0 05?>0 05?>0 05 respectively and liver fibrosis reduced after treatment The expression of LN,CⅣ in liver histology were retrained notebly afer therapy It is concluded that IFN α can restrict or reduce liver fibrosis in patients with CHB

关 键 词：Α-干扰素 肝纤维化 透明质酸 层粘蛋白 IV型胶原 免疫组织化学 

分 类 号：R575.2[医药卫生—消化系统] R512.62[医药卫生—内科学]