第1个反义药物——福米韦生  

The first antisense drug-fomivirsen

作　　者：边琪[1] 缪朝玉[1] 楚正绪[1] 苏定冯[1] 

机构地区：[1]中国人民解放军第二军医大学基础部药理学教研室,上海200433

出　　处：《中国新药与临床杂志》2002年第5期300-303,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：福米韦生 (fomivirsen)是FDA批准上市的第一个反义药物 ,由 2 1个硫代脱氧核苷酸组成。通过对人类巨细胞病毒 (CMV)mRNA的反义抑制发挥特异而强大的抗病毒作用 ,用于局部治疗艾滋病(AIDS)病人并发的CMV视网膜炎。疗效维持久 ,给药次数少 ,不良反应轻。Fomivirsen is the first antisense drug approved by FDA. It is composed of 21 phosphorothioate nucleotides, and used for the local treatment of cytomegalvirus (CMV) retinitis in patients with AIDS. The antiviral mechanism of fomivirsen is mainly due to antisense inhibition of human CMV mRNA, which makes it produce specific and potent inhibition of human CMV replication. This new agent has several advantages, including long-lasting curative effects (1 wk at least), less administration frequency, and few adverse reactions. The review focuses on the pharmacology and clinical study of fomivirsen.

关 键 词：反义药物 福米韦生 视网膜炎 反义寡核苷酸 抗病毒药 治疗 疗效 

分 类 号：R978.7[医药卫生—药品] R774.11[医药卫生—药学]