唾液酸化LewisX与P16蛋白在大肠癌表达的对比研究  

EXPRESSIONS OF SIALYL LEWIS X AND P16 IN COLORECTAL CARCINOMA AND THEIR RELATIONSHIPS WITH MALIGNANT PROCLIVITY

作　　者：尚培中[1] 谷化平[1] 孙印臣[1] 刘景章[1] 卢育奇[1] 王佩玲[1] 朱习琴[1] 

机构地区：[1]解放军第251医院

出　　处：《解放军医学杂志》2002年第4期325-326,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：为了探讨唾液酸化LewisX和P16在大肠癌表达及其与肿瘤发生发展、浸润转移和预后的关系 ,应用免疫组化微波 LSAB法检测 90例大肠癌唾液酸化LewisX和P16蛋白的表达状况。结果显示 ,大肠癌组织唾液酸化LewisX和P16表达阳性率分别为92 2 %和 4 2 2 % ,唾液酸化LewisX高表达和P16低表达与大肠癌转移和预后有关。提示联合检测唾液酸化LewisX和P16更有助于判断大肠癌恶性程度。This study was conducted to study the expressions of sialyl Lewis X and P16 protein in colorectal carcinoma and their relationship with differentiation, metastasis and prognosis of colo rectal carcinoma. Sialyl Lewis X and P16 expressions were determined with microwave-LSAB immunohistochemical technique. The positive rates of sialyl Lewis X and P16 were 92.2% and 42.2% respectively. The increased expression of sialyl Lewis X and the weakened expression of P16 were significantly correlated with metastatic proclivity and poor prognosis of the malignancy. These findings indicated that combined examination of the expression of sialyl Lewis X and P16 might be useful in estimating the differentiation, infitrtion, metastasis of colo-rectal carcinoma and prognosis of the patients.\;

关 键 词：细胞粘附分子 唾液酸化LEWIS X 蛋白质P16 免疫组织化学 大肠癌 预后 临床意义 

分 类 号：R735.34[医药卫生—肿瘤]