小儿自体外周血造血干细胞移植近期和远期毒副作用的研究  

ACUTE AND LATE SIDE-EFFECTS OF AUTOLOGOUS PERIPHERAL BLOOD STEM CELL TRANSPLANTATION IN PEDIATRIC PATIENTS

作　　者：王建文[1] 田晨杰[1] 唐锁勤[1] 吕善根[1] 彭橘云[1] 冉丛蓉[1] 魏晓军[1] 黄东升[1] 

机构地区：[1]解放军总医院

出　　处：《解放军医学杂志》2002年第4期366-368,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：探讨小儿自体外周血造血干细胞移植预处理的近期和远期毒副作用 ,按Bearmen标准评价 2 1例接受治疗患儿的急性相关毒性反应 ,并对 11例术后生存 3年以上患儿随访。 14例无任何急性毒性反应 ;5例为Ⅰ级 ;2例为Ⅱ级。全部患儿身高及神经精神发育正常 ;2例有代偿性甲状腺功能低下 ;1例性腺发育延迟 ;6例轻度白内障 ;7例病毒性肝炎。提示患儿能耐受合适的预处理 ,远期影响小 ,生存质量高 ;To investigate the acute and late side effects of autologous peripheral blood stem cell transplantation (Auto PBSCT) in children. Acute toxicity was evaluated in 21cases, according to Beurmen criteria. 11 patients who lived longer than 3 years after Auto PBSCT were followed up. Acute toxicity was mild. Growth and neuropsychological development were normal. Two children developed slight compensated hypothyroidism. Puberty was delayed in one male patient. Mild cataract was noticed in six children. Seven patients were found to suffer from hepatitis. The results suggested that pediatric patients were able to tolerate an appropriate pre conditioning regimen. Attention shoud be paid to the prevention of hepatitis.

关 键 词：造血干细胞移植 自体移植 随访研究 外周血 小儿 恶性肿瘤 毒性反应 

分 类 号：R730.59[医药卫生—肿瘤]