MMP-9与TIMP-1在TCCB中的表达和意义  

Expression and Significance of MMP-9 TIMP-1 in Human Transitional Cell Carcinoma of Bladder

作　　者：杜广[1] 牧荣[1] 云志中[1] 顾剑锋[1] 

机构地区：[1]内蒙古自治区医院泌尿外科,病理科,内蒙古呼和浩特010017

出　　处：《内蒙古医学杂志》2002年第2期95-98,共4页Inner Mongolia Medical Journal

摘　　要：目的和方法：运用免疫组化技术ＳＰ法检测ＭＭＰ　－９、ＴＩＭＰ－１在６８例膀胱移行细胞癌中的表达，分析它们与临床病理分级、分期的关系。旨　在探寻它们在膀胱移行细胞癌（ＴＣＣＢ）浸润、转移中的作用。结果：ＭＭＰ－９在ＴＣＣＢ中高表达，　４１／６８例阳性，阳性率为６０％。ＭＭＰ－９的表达阳性率随肿瘤分级、分期的升高而增加　（Ｐ＜０．０５）。ＴＩＭＰ－１在ＴＣＣＢ中高表达，３１／６８例阳性，阳性率为４５．５％。ＴＩＭＰ－１的　表达随肿瘤分级、分期的增加而呈下降趋势（Ｐ＜０．０５）。ＭＭＰ－９在ＴＣＣＢ的表　达与ＴＩＭＰ－１的表达经统计学分析有相关性。ＭＭＰ－９（＋）／ＴＩＭＰ－１（－）表达在浸润性或高分级　肿瘤中则比例较高，差异有统计学意义（Ｐ＜０．０５）。结论：ＭＭＰ－９和ＴＩＭＰ－　１与ＴＣＣ　Ｂ的分级和分期相关，ＭＭＰ－９及ＴＩＭＰ－１的差异表达对于ＴＣＣＢ的侵袭发展发挥了重要作用。Purpose and Methods:The expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 were s tudied by SP immunohistochemistry in 68 cases of transitional cell carcinoma of bladder to investigate the relationship of the expression and clinicopathologica l parameters.Results:The expression of MMP-9 and TIMP-1 were higher in TCCB.The expression rate of MMP-9 was 60% and was elevated with grade and stage.The expre ssion rate of TIMP-1 was 45.5%.There was a inverse relationship between the expr ession rate and grade or stage.It was found that the tumors expressed MMP-9(+)/T IMP-1(-) had higher pathological stage and grade than the groups expressed MMP-9 (-)/TIMP-1(+).Conclusions:The expressions of MMP-9 and TIMP-1 be correlated with grade and stage of TCCB.The increased MMP-9 expression and decreased TIMP-1 exp ression were associated with the invasion and development of TCCB.

关 键 词：膀胱移行细胞癌 MMP-9 TIMP-1 免疫组化 

分 类 号：R737.14[医药卫生—肿瘤] R730.21[医药卫生—临床医学]