人类天然抑瘤物净化骨髓在缓解或复发白血病自体移植中应用  

Autologous Bone Marrow Transplantation with Natural Tumor Suppressor of Human Purged Marrow for Acute Nonlymphocytic Leukemia in First Remission or Early Relapse

作　　者：纪树荃[1] 王伟光[1] 刘智明[1] 乔爱珍[1] 王冬芳[1] 李玉云[1] 吴祖泽[2] 裴雪涛[2] 

机构地区：[1]空军总医院血液科 [2]军事医学科学院

出　　处：《空军总医院学报》1992年第3期132-135,共4页Journal of General Hospital of Air Force,PLA

摘　　要：7例急性髓系白血病经大剂量化疗或放疗加化疗预处理后，输回经小分子抑瘤物净化骨髓，平均中性粒细胞达0.5×10^9/L37天，血小板达20×10^7/L35天，2例早期复发接受移植病例分别于移植后30天，150天复发。结果提示，白血病复发期中行移植的疗效差，用人类胎肝小分子抑瘤物净化骨髓对正常祖细胞生长无影响。Seven patients with acute myeloid leukemia were treated with high-dose chemotherapy or chemoradiotherapy followed by infusion of autologous marrow purged in liqued culture system supplemented with low molecular weight natural tumor suppressor of human fetal liver origin. The marrow harvests were performed when there were<5% blasts in five patients and≥5% blast in two patients in marrow. The median time to achieve 500 neutrophils/μl was 37 days. A platelet count of 20000/μl was achieved at median of 35 days.Two of seven patients with early relapse have relapsed at 30 and 150 days, respectively. There was a trend toward improved relapse-free survival for patients transplanted in remission as opposed to those transplanted in relapse and the low molecular weight natural tumor suppressor suppressed the blast progenitor of AML and had a less harmful effect on the growth of normal marrow cells.

关 键 词：急性白血病 自体骨髓移植 疗效 小分子抑瘤物 复发髓细胞白血病 白血病克隆形成单位 

分 类 号：R733.71[医药卫生—肿瘤]