糖类抗原19-9在膀胱癌患者尿液中异常表达  

Study on the abnormal expression of carbohydrate antigen 19-9 in the urine samples of the patients with bladder cancer

作　　者：陆云[1] 袁鲲[1] 邓守真[1] 林祥通[1] 张元芳[1] 

机构地区：[1]复旦大学附属华山医院,上海200040

出　　处：《核技术》2002年第5期367-370,共4页Nuclear Techniques

摘　　要：通过检测膀胱癌患者尿液中糖类抗原 1 9- 9(CA1 9- 9)的含量 ,分析并评估其对诊断膀胱癌的临床价值。用全自动化学荧光系统检测膀胱癌患者 (3 0例 ) ,泌尿系统常见良性疾病 (5 3例 )、恶性疾病 (2 2例 )和其它系统恶性肿瘤 (3 5例 )患者以及 3 0例为既往无各系统恶性肿瘤和泌尿系统病史的志愿者 (对照组 )尿液中CA1 9- 9含量。结果显示 ,膀胱癌组CA1 9- 9含量水平为 1 5 9.0± 1 2 8.0U/mL。对照组的尿CA1 9- 9含量水平为 1 2 .4± 8.4U/mL。以对照组均值± 1 .96SD为临界点 ,即大于 2 8.9U/mL为阳性。膀胱移行细胞癌诊断灵敏度 86.7%、特异性 68.2 %。膀胱癌组与对照组的尿CA1 9- 9含量差异有显著统计意义 (P <0 .0 0 1 ) ,与其它各组差异也有显著统计意义 (P <0 .0 0 1 )。良性泌尿系统疾病组尿CA1 9- 9含量水平为 5 3 .9± 77.9U/mL ,明显高于对照组 (P =0 .0 0 1 ) 。To investigate the levels of carbohydrate antigen 19-9 in the urine samples of the patients with bladder cancer and to evaluate its clinical diapnostic value. Urine samples were taken from 30 patients with bladder cancer, 53 with benign, 22 with malignant urological diseases and 35 with malignant tumors from other systems, together with 30 normal subjects which have no any history of cancers or other urological diseases. CA19-9 was assayed by Chiron Diagnostic Corporation ACS:180SE. The CA19-9 level of the group with bladder cancer was 159.0±128.0U/mL, while that of the group of control was 12.4±8.4U/mL. The critical points were determined as the mean value of the group of control ±1.96 SD , then >28.9U/mL was considered as positive. The diagnostic sensitivity for bladder TCC were 86.7% and specificity were 68.2%. CA19-9 level in the bladder cancer group was significantly different from that of control group ( P <0.001), and also different from those of other groups. The urine CA19-9 level in the group of benign urological diseases was 53.9±77.9%, significantly higher than that of control ( P =0.001), but not significantly different from those of the group of other urological cancers and other systems cancers. Preliminary study indicates that CA19-9 urine samples study is a non-invasive auxiliary index for the clinical diagnosis of bladder cancer. The method is simple and useful. But the interference from other benign and malignant diseases as well as gene-types should be considered in clinical practice.

关 键 词：尿液 膀胱癌 糖类抗原19-9 肿瘤标记物 诊断 

分 类 号：R737.14[医药卫生—肿瘤] R730.44[医药卫生—临床医学]