谷胱苷肽S转移酶在口腔鳞癌中的表达  

Expressions of GST-π in oral leukoplakia and oral squamous cell carcinoma

作　　者：郑小草[1] 刘创峰[1] 王爱康 

机构地区：[1]宁波市第一医院,315010 [2]宁波市第三医院

出　　处：《现代实用医学》2002年第4期175-176,共2页Modern Practical Medicine

摘　　要：目的　研究异型增生程度不同的口腔白斑和不同分级的鳞癌中谷胱苷肽S转移酶π(GST π)的表达 ,探讨GST π在口腔鳞癌发生发展中的作用。　方法　采用免疫S -P法 ,对 5 4例轻、中、重度异型增生 ,4 7例高、中、低分化的口腔鳞癌 ,7例口腔粘膜上皮单纯增生患者组织进行GST π检测。　结果　口腔粘膜上皮单纯增生组织中未见GST π的表达 ,轻、中、重度异型增生病例中的GST π阳性率分别为4 7.8%、5 2 .9%和 6 4 .2 % ,高于单纯增生组 (P <0 .0 1) ;高分化鳞癌GST π阳性率为 6 4 .7% ,中、低分化鳞癌组分别为 2 8.5 %及 2 2 .2 % ,中、低分化鳞癌组表达均低于高分化鳞癌组及异型增生组 (P <0 .0 5 )。　结论　GSTObjective To investigate the expressions of Glutathione S transferase π in tissues of oral leukoplakia and oral squamous cell carcinoma. Methods Using immunohistochemistry S P method,the paraffin embedded tissues from 54 patients with oral epithelial dysplasia,47 patients with oral squamous cell carcinoma,and 7 patients with oral epithelial hyperplasia were detected for the expression of GST π. Results There was no positive expression of GST π in the tissues of oral epithelial hyperplasia.The positive rates of GST π expression in mild,moderate,and severe dysplastic tissues was 47.8%,52.9% and 64.2%, respectively. The positive rates of GST π expression in tissues of squamous cell carcinoma with lower,moderate and higher differentiation was 64.7%,28.5% and 22.2%,respectively. Conclusion The changes of GST π expression may be closely related to early development of oral squamous cell carcinoma.

关 键 词：口腔白斑 免疫组织化学 病理学 谷胱苷肽S转移酶 口腔鳞癌 

分 类 号：R739.85[医药卫生—肿瘤]