EEG与SEP对大鼠局灶性脑缺血损伤程度评价  

Evaluation of EEG and SEP on the extent of brain damage following focal ischemia/reperfusion in rats

作　　者：李广仁[1] 朱丹[1] 李大伟[1] 

机构地区：[1]吉林大学第一医院神经内科,吉林长春130021

出　　处：《中风与神经疾病杂志》2002年第2期98-100,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的　探讨脑电图 (EEG)、体感诱发电位 (SEP)在评价局灶脑缺血再灌性脑损伤程度中的意义 ,以及对缺血再灌性脑损伤的影响。方法　制备大脑中动脉阻塞 (MCAO)模型 ,之后在缺血再灌不同时间记录 EEG、SEP变化 ,结合组织病理进行损伤程度评价。结果　缺血组在 (MCAO)早期即出现脑电波消失 ,SEP潜伏期延长 ,波幅降低 ,再灌后有一定恢复。组织学呈现与其相应的改变。结论　 EEG。Objective To find out the meaning of EEG and SEP on evaluating the extent of brain damage following focal cerebral ischemia/reperfusion and the influence on brain injury. Methods MCAO model was made in ischemic group. And then EEG and SEP were observed in different times of ischemia/ reperfusion to evaluate the extent of brain damage combined with pathology change.Results In the early stage of MCAO , we found that brain wave vanished , latency period of SEP lengthened and ampulitude got down . These changes recovered at the different extent after reperfusion. Conclusions EEG and SEP are valuable and sensitive indexes to evaluate the extent of ischemic cerebral lesions.

关 键 词：脑电图 体感诱发电位 动脉阻塞 局灶性脑缺血 缺血性脑损伤 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]