人参三醇组甙对小鼠骨髓细胞染色体辐射的防护作用  

Radioprotective effect of panaxatriol on chromosome of bone marrow cells in mouse

作　　者：刘丽波[1] 孙晓玲[1] 张海英[1] 梁硕[1] 马兴元[2] 李效昆[3] 刘树铮[1] 

机构地区：[1]吉林大学放射医学研究所,吉林长春130021 [2]吉林大学基础医学院有机化学教研室 [3]暨南大学生物工程研究所

出　　处：《吉林大学学报（医学版）》2002年第2期138-140,共3页Journal of Jilin University：Medicine Edition

摘　　要：目的 :研究人参三醇组甙 ( Panaxatriol,PT)对受照射小鼠骨髓细胞染色体的辐射防护作用。方法 :小鼠照射前胃肠道给予 PT,照射后 3h杀鼠制备骨髓细胞染色体标本。结果 :辐照前给予2 0 0～ 40 0 mg· kg-1PT可降低辐射诱发的骨髓细胞染色单体型和染色体型畸变以及畸变细胞数 ,且给药剂量和给药时间与其呈正相关 ,照射剂量与防护效应呈负相关。结论Objective:To study the radioprotective effect of panaxatriol (PT) on chromosomes in bone marrow cells of X irradiated mice. Methods:Mice were treated with PT or normal saline (the control group) before irradiation and killed 3 h after irradiation then prepared the chromosome samples of bone marrow cells. Results:200~400 mg·kg -1 PT reduced the frequency of chromatid breaks and chromosome aberrations as well as the number of aberrant cells induced by X rays. The radioprotective effect was positively correlated with the dose of PT and the duration of drug administration, while negatively with the doses of X rays. Conclusion:PT has significant radioprotective effect on chromosomes of mouse bone marrow cells.

关 键 词：人参三醇组甙 染色体畸变 辐射防护 骨髓细胞 动物实验 放射损伤 

分 类 号：R818.74[医药卫生—放射医学] R285.5[医药卫生—临床医学]