A型肉毒毒素与力奥来素治疗肌痉挛的疗效对比  

Botulinum toxin A and lioresal for managing spasticity:clinical comparative study

作　　者：刘卫[1] 李玲[1] 王冰水[1] 牟翔[1] 王斌[1] 

机构地区：[1]解放军第四军医大学西京医院,陕西西安710032

出　　处：《中国临床康复》2002年第8期1103-1104,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的比较A型肉毒毒素(BTXA)与力奥来素对缓解肌痉挛的疗效。方法将45例患者随机分为BTXA治疗组(B组)和力奥来素治疗组(L组)。对B组22例患者共47块痉挛明显的肌肉进行注射BTXA治疗,对L组23例患者采取口服力奥来素治疗。采用改良Ashworth痉挛评分法,分别在治疗前、治疗2周、治疗4周对两组患者进行评定。结果两组患者在治疗2周时都较治疗前肌张力明显降低(P<0.01),但两组比较,B组比L组降低肌张力更为明显,两组差异非常显著(P<0.01)。B组4周时与2周比较无明显差异(P>0.05),L组4周与2周比较肌张力进一步降低,有显著差异(P<0.01)。两组在4周时比较差异不显著(P>0.05)。结论观察证实:两种治疗均能有效缓解肌痉挛,但BTXA起效较快,较充分,更利于患者早期功能训练。Objective To compare botulinum toxin A (BTXA) with Lioresal for managing spasticity.Method Forty five patients with spasticity were randomly allocated to one of two treatment groups.Twenty two patients received BTXA injection(group B) and twenty three patients received oral Lioresal (group L).The effect of treatment was assessed with Modified Ashworth Scale at before treatment and 2 weeks and 4weeks after treatment.Result The outcome showed significant improvements for both groups at 2 weeks and 4 weeks after treatments (P< 0.01).BTXA was more effective than Lioresal at 2weeks , the difference was significant (P< 0.01).There was no significant difference between the two groups at 4weeks(P >0.05).Conclusion The result showed that both BTXA and Lioresal were effective for muscular relaxation.The effect of BTXA occurred earlier than Lioresal,it was better for early functional training.

关 键 词：A型肉毒毒素 治疗方法 力奥来素 肌痉挛 疗效 改良Ashworth痉挛评分法 

分 类 号：R746[医药卫生—神经病学与精神病学]