豚鼠-大鼠异种异位心脏移植模型的建立  

A model of guinea-pig to rat heart heterotopic xenotransplantation established

作　　者：李军[1] 杨康[1] 

机构地区：[1]第三军医大学西南医院胸心外科,重庆400038

出　　处：《重庆医学》2002年第5期357-358,共2页Chongqing medicine

摘　　要：目的　建立简便易行的异种心脏异位移植动物模型。方法　采用改良Ono术式行豚鼠 大鼠异种异位心脏移植。结果　进行正式实验 6 0例 ,成功率为 90 % ,移植后平均存活时间为 (30± 8)min ,主要失败原因为麻醉意外、吻合口出血。结论这种模型操作简便 ,重复性好 ,适合研究选用。Objective To establish a simple heart heterotopic xenotransplantation animal model. Methods Guinea pig to rat heterotopic cardiac transplantation were performed using modified Ono procedure. Results Rate of success was 90%.Mean survive time was (30±8)min.The failure reasons included anastomotic bleeding and anesthetic accident. Conclusion This model proves to be relatively simple,stable and practicable, to be used in experimental study .

关 键 词：异种移植 心脏移植 豚鼠 大鼠 异位移植 动物模型 

分 类 号：R-332[医药卫生]