氨甲喋呤+更生霉素短程疗法对恶性滋养细胞瘤的治疗  

A Short-term Therapy with Methotrexate and Kengshengmycin for Treatment of Malignant Gestational Trophoblastic Neoplasms

作　　者：林美华[1] 

机构地区：[1]同济医科大学附属协和医院妇产科

出　　处：《同济医科大学学报》1991年第3期180-182,共3页Acta Universitatis Medicinae Tongji

摘　　要：本文报道1982～1987年20例恶性滋养细胞瘤患者,单纯应用氨甲喋呤+更生霉素短程化疗(5d)的近期疗效及随访结果,20例患者均获得完全缓解。随访19例,3年治愈率达100％,除6例采取避孕措施外,余13例化疗后均有正常孕产史,所产16个婴儿未见畸形,发育和智力均正常。此方案药源充分、方法简单、疗效好,化疗毒性反应韵发生率及程度均低于常规疗法。This paper presents a report of the immediate therapeutic effects and the results of long-term follow-up of the patients with malignant gestational trophoblastic neoplasms treated with short-term chemotherapy alone. From 1982 through 1987, we have used methotrexate and kengshengmycin to treat 20 cases of invasive mole and choriocarcinoma with each course lasting 5 days. All of the patients achieved complete remission (100 %). Nineteen of them have been fol-lowed-up for more than 3 years, in whom no recurrence was observed. Except for 6 patients practising contraception, 13 had normal pregnancy and parturition after chemotherapy, thus bearing a total of 16 children who did not have congenital anomalies and had normal growth, development and intelligence. This method of treatment is effective, simple and easy to apply with supply with drugs readily available in the market. In addition, the degree and incidence of chemotherapeutic toxic reactions is lower than with conventional therapy.

关 键 词：滋养细胞瘤 氨甲喋呤 更生霉素 

分 类 号：R737.330.5[医药卫生—肿瘤]